A0A3Q1MZ99 · A0A3Q1MZ99_BOVIN

  • Protein
    Lymphoid enhancer binding factor 1
  • Gene
    LEF1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Features

Showing features for dna binding.

141450100150200250300350400
TypeIDPosition(s)Description
DNA binding299-367HMG box

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbeta-catenin-TCF complex
Cellular Componentchromatin
Cellular Componentcytoplasm
Cellular Componentprotein-DNA complex
Molecular Functionarmadillo repeat domain binding
Molecular Functionbeta-catenin binding
Molecular FunctionC2H2 zinc finger domain binding
Molecular Functionchromatin binding
Molecular FunctionDNA binding, bending
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functiongamma-catenin binding
Molecular Functionhistone deacetylase binding
Molecular Functionnuclear estrogen receptor binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functiontranscription corepressor binding
Molecular Functiontranscription regulator inhibitor activity
Biological Processanatomical structure regression
Biological Processapoptotic process involved in blood vessel morphogenesis
Biological ProcessB cell proliferation
Biological ProcessBMP signaling pathway
Biological Processbranching involved in blood vessel morphogenesis
Biological Processcanonical Wnt signaling pathway
Biological Processcell chemotaxis
Biological Processcellular response to interleukin-4
Biological Processchorio-allantoic fusion
Biological Processdentate gyrus development
Biological Processembryonic limb morphogenesis
Biological Processepithelial cell apoptotic process
Biological Processepithelial to mesenchymal transition
Biological Processface morphogenesis
Biological Processforebrain neuroblast division
Biological Processforebrain radial glial cell differentiation
Biological Processformation of radial glial scaffolds
Biological Processmammary gland development
Biological Processnegative regulation of apoptotic process in bone marrow cell
Biological Processnegative regulation of interleukin-13 production
Biological Processnegative regulation of interleukin-4 production
Biological Processnegative regulation of interleukin-5 production
Biological Processnegative regulation of striated muscle tissue development
Biological Processneutrophil differentiation
Biological Processodontogenesis of dentin-containing tooth
Biological Processosteoblast differentiation
Biological Processparaxial mesoderm formation
Biological Processpositive regulation by host of viral transcription
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of cell proliferation in bone marrow
Biological Processpositive regulation of chondrocyte proliferation
Biological Processpositive regulation of epithelial to mesenchymal transition
Biological Processpositive regulation of gamma-delta T cell differentiation
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of granulocyte differentiation
Biological Processpositive regulation of odontoblast differentiation
Biological Processpositive regulation of Wnt signaling pathway
Biological Processprotein localization to chromatin
Biological Processregulation of transcription by RNA polymerase II
Biological Processsecondary palate development
Biological Processsensory perception of taste
Biological Processsomitogenesis
Biological Processsprouting angiogenesis
Biological ProcessT cell receptor V(D)J recombination
Biological ProcessT-helper 1 cell differentiation
Biological Processtongue development
Biological Processtrachea gland development
Biological Processtranscription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Submitted names
    • Lymphoid enhancer binding factor 1

Gene names

    • Name
      LEF1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1MZ99

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-104Disordered
Compositional bias21-53Basic and acidic residues
Compositional bias81-99Basic and acidic residues
Region166-193Disordered
Region268-300Disordered
Compositional bias271-300Basic and acidic residues
Domain299-367HMG box
Region369-414Disordered

Sequence similarities

Belongs to the TCF/LEF family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    414
  • Mass (Da)
    45,762
  • Last updated
    2019-04-10 v1
  • Checksum
    B5B502D741FDF4AB
MPQLSGAGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESEIIPASNGHEVARQAQTSQESYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNMNNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPEIPTFYPLSPGGVGQITPPLGWQGQPVYPITGGFRQPYPSSLSVDTSMSRFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESTSGGKRSSFPTCKAKAATPGPLLEMEAC

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E1BJ93E1BJ93_BOVINLEF1399
A0A3Q1MAH2A0A3Q1MAH2_BOVINLEF1386
A0AAA9SCM1A0AAA9SCM1_BOVINLEF1237
A0AAA9SB85A0AAA9SB85_BOVINLEF1303

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias21-53Basic and acidic residues
Compositional bias81-99Basic and acidic residues
Compositional bias271-300Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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