A0A3Q1MEI8 · A0A3Q1MEI8_BOVIN

  • Protein
    NADPH--cytochrome P450 reductase
  • Gene
    POR
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per monomer.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site41-46FMN (UniProtKB | ChEBI)
Binding site93-96FMN (UniProtKB | ChEBI)
Binding site128-137FMN (UniProtKB | ChEBI)
Binding site163FMN (UniProtKB | ChEBI)
Binding site253NADP+ (UniProtKB | ChEBI)
Binding site379FAD (UniProtKB | ChEBI)
Binding site409-412FAD (UniProtKB | ChEBI)
Binding site427-429FAD (UniProtKB | ChEBI)
Binding site433FAD (UniProtKB | ChEBI)
Binding site443-446FAD (UniProtKB | ChEBI)
Binding site490NADP+ (UniProtKB | ChEBI)
Binding site551-552NADP+ (UniProtKB | ChEBI)
Binding site557-561NADP+ (UniProtKB | ChEBI)
Binding site594NADP+ (UniProtKB | ChEBI)
Binding site632FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH--cytochrome P450 reductase
  • EC number
  • Short names
    CPR
    ; P450R

Gene names

    • Name
      POR

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1MEI8

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain35-179Flavodoxin-like
Domain234-476FAD-binding FR-type

Sequence similarities

Belongs to the NADPH--cytochrome P450 reductase family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    633
  • Mass (Da)
    71,926
  • Last updated
    2024-05-29 v2
  • Checksum
    D3A0C0496F6302FE
MGCTYSAHQDEPIPRTSSVKDRSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMAADPEEYDLADLSSLPEIEKALAIFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKYAVFALGNKTYEHFNAMGKYVDKRLEQLGAQRIFDLGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELMVHTDMDMAKVYTGEMGRLKSYENQKPPFDAKNPFLAVVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGEILGADLDIIMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPTEHEQLRKMASSSGEGKELYLRWVLEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYETKTGRINKGVATSWLRAKEPAGENGGRALVPMYVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAGFHKDGALTQLNVAFSREQLQKVYVQHLLKKDKEHLWKLIHEGGAHIYVCGDARNMARDVQNTFYDIVAEQGAMEHAQAVDYVKKLMTKGRYSLDVWS

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3S5ZP34A0A3S5ZP34_BOVINPOR714
A0A3Q1MSC4A0A3Q1MSC4_BOVINPOR648
A0A3Q1MQF2A0A3Q1MQF2_BOVINPOR702
A0A3Q1M7U0A0A3Q1M7U0_BOVINPOR681

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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