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A0A3Q1MCM6 · A0A3Q1MCM6_BOVIN

  • Protein
    Voltage-dependent T-type calcium channel subunit alpha
  • Gene
    CACNA1I
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Features

Showing features for binding site.

121862004006008001,0001,2001,4001,6001,8002,000
TypeIDPosition(s)Description
Binding site353Ca2+ (UniProtKB | ChEBI)
Binding site780Ca2+ (UniProtKB | ChEBI)
Binding site1338Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionmetal ion binding
Molecular Functionvoltage-gated calcium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent T-type calcium channel subunit alpha

Gene names

    • Name
      CACNA1I

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1MCM6

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane78-97Helical
Transmembrane117-137Helical
Transmembrane204-228Helical
Transmembrane341-362Helical
Transmembrane368-393Helical
Transmembrane721-743Helical
Transmembrane763-779Helical
Transmembrane799-821Helical
Transmembrane1129-1147Helical
Transmembrane1167-1188Helical
Transmembrane1200-1226Helical
Transmembrane1264-1286Helical
Transmembrane1365-1389Helical
Transmembrane1445-1462Helical
Transmembrane1482-1501Helical
Transmembrane1580-1599Helical
Transmembrane1666-1688Helical

Keywords

  • Cellular component

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

Type
IDPosition(s)Description
Region1-47Disordered
Compositional bias24-42Pro residues
Domain81-404Ion transport
Region461-496Disordered
Region508-549Disordered
Compositional bias522-539Polar residues
Region555-574Disordered
Domain599-827Ion transport
Region954-1017Disordered
Compositional bias992-1014Basic residues
Domain1127-1399Ion transport
Coiled coil1398-1425
Domain1445-1698Ion transport
Region1714-1753Disordered
Region1830-1851Disordered
Region1893-1915Disordered
Compositional bias1967-1993Polar residues
Region1967-2186Disordered
Compositional bias2036-2055Polar residues
Compositional bias2155-2177Pro residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,186
  • Mass (Da)
    241,398
  • Last updated
    2019-04-10 v1
  • MD5 Checksum
    B5872D0DFBE9C204904349122CEE9D30
MAENSPPPPSPTAARVAEPGVTEQPGPQSPPPSPPGPEEPLDGVDPEVPHPDLAPVAFFCLRQTTSPRNWCIKMVCNPYPFMLVILLNCVTLGMYQPCDDMDCLSERCKILQVFDDFIFVFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALRSRRQAAGMPGSATPGPRAKEPRHYKLCPRHSPLDPTPHTLVQPISAMLASDPASCPRCQHESDRRPSGQGSSSDSGQEGSGSGDAVGSEDEVGADVARTSEDGASLELGKEDEEGPADGAARLCEDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHQQPEELTNILEICNVVFTSMFALEMLLKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNMEEFDKLQEGLDCSGDPKLCPIPMTPNGHLDPNLPLGGHLGPTGAAASAPRLSLQPDPVLMALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSGAWASRRSSWNSLKHKQPSAEHESLLSAERGGARGCEGARDEGPLRTAPLHAPHAHHAHHGPHPVHRHHHHRRTLSLDTRDSVDLAELVPAVGTHSRAAWRAAGLAPGHEDCNGRMPSIAKDVFTKMDDRRDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVPNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCPTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELELAHGLGPSPRPPASAPGAPAPAHGPGGATGGEPGRQPVPAHPENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCEKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPAACPVGPRDSKGEPDPPEPMQVGDLGECFFPLPNTAVSSGPENFLCEMEAIPFNPVQSWLKHESSQAPPSPFSPDASSPLLPMPAEFFHPAVAASQEGQEKGAGSRTLPKIALQGSWASLRSPSVNCTLLRQATGSDTSLEVSRSSSAGSLQTTLEDSLTLSDSPRRGLGLPASVPGPRAGPSPAARRRPSPRGRGTFSLRGLRAHQRSHSSGGSTSPGCTRHDSMDPSDEEGAGGRAGGGCGGAGSEHSETLSSLSLTSLFGPPPPPPGLPPARRFSSASSLAAGPGRPRAAAAPGPHGLARSPSWAAADRCKDPPRPAEPAAPRDPEAPEPQPPPPPPGEPPSGDAASQGRR

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1LLQ8A0A3Q1LLQ8_BOVINCACNA1I1777
A0A3Q1LL52A0A3Q1LL52_BOVINCACNA1I1738
A0A3Q1N5J4A0A3Q1N5J4_BOVINCACNA1I1745
A0A3Q1MXV9A0A3Q1MXV9_BOVINCACNA1I1789
G3MWH6G3MWH6_BOVINCACNA1I1850
G3N292G3N292_BOVINCACNA1I1836
G3N034G3N034_BOVINCACNA1I1727
A0A3Q1MJ23A0A3Q1MJ23_BOVINCACNA1I1921
A0A3Q1MMH5A0A3Q1MMH5_BOVINCACNA1I2218

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias24-42Pro residues
Compositional bias522-539Polar residues
Compositional bias992-1014Basic residues
Compositional bias1967-1993Polar residues
Compositional bias2036-2055Polar residues
Compositional bias2155-2177Pro residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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