A0A3Q1MCC5 · A0A3Q1MCC5_BOVIN

  • Protein
    Thyroid peroxidase
  • Gene
    TPO
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site493Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Molecular Functionheme binding
Molecular Functionperoxidase activity
Biological Processorganic acid metabolic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thyroid peroxidase
  • EC number

Gene names

    • Name
      TPO

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1MCC5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane790-811Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Interacts with DUOX1, DUOX2 and CYBA.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain681-737Sushi
Domain737-780EGF-like

Sequence similarities

Belongs to the prostaglandin G/H synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    870
  • Mass (Da)
    94,829
  • Last updated
    2024-05-29 v2
  • Checksum
    0035FC7087EF70B8
MRARAVLGVVLAVTCAGAVFSFLLRPGGLLWGETEESQVRGIVEASRLLVDKSVYAAMRRNLHKREVISPAQLLSFSKLPEPTSRAASRAAEVMEASVQEAARRGHLRSGPSQLPTDALSEGLLSAIANLSGCLPYMLPPRCPATCLASKYRLISGACNNRDHPRWGASNTALARWLPPAYEDGISEPRGWNPHFLYKGFPLPPVREVTRRIIHASNEAVTGDDRYSDLLTAWGQYIDHDIAFTPQSAAPSAPWVGADCQLTCEPRSPCFPIQLPQLPANAAGPACLPFYRSTAACGTGTQGALFGNLSSANPRQQMNGLTSFLDASTVYGSSAASERRLRNWTSAEGLLRVNARYRDAGRAFLPFAPPSAPPACAPQPGAPGARAPCFLAGDGRASEVPALAALHTLWLREHNRLATALKALNAHWSADTAYQEARKVVGALHQIITLRDYVPRILGPEAFGRHVGPYRGYDPSVDPTVSNVFSTAAFRFGHATIHPLVQRLDARFQEHLGPRLLLRDAFFRPWRLLEEGYNEWRQFCGLSRLETRADLGAATANGSMADRILDLYGHPDNIDVWLGGLAETFLPGARTGPLFACLVGKQMKALRDGDRFWWEHRAVFTEAQRRELGRHSLSRVICDNTGLTRVPRDAFRVGQWPQDFESCDRIPGMDLRAWREAPPPDDACGFPDKVENGGFLLCDESGRRVLVFSCHHGFQLQGPEQVTCTRHGWDSQPPVCRDINECEDEVDPPCHASARCKNTKGSFQCECSDPHVPGEDGRTCVDSGRLPRASVVSLVLGAMLVCSLAGLTWTVVCRWMLADPTSPLLPVEGDGEGPSWLGRGKPRDVCTPPRDASAGLAEQGPACGSQVLLCK

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1M790A0A3Q1M790_BOVINTPO927
A0A3Q1LK39A0A3Q1LK39_BOVINTPO826
A0A3Q1NAI2A0A3Q1NAI2_BOVINTPO755

Keywords

Genome annotation databases

Similar Proteins

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