A0A3Q1MCC5 · A0A3Q1MCC5_BOVIN
- ProteinThyroid peroxidase
- GeneTPO
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids870 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.
Catalytic activity
- 2 H+ + H2O2 + 2 iodide = diiodine + 2 H2O
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | heme binding | |
Molecular Function | peroxidase activity | |
Biological Process | organic acid metabolic process | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThyroid peroxidase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A3Q1MCC5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 790-811 | Helical | ||||
Sequence: VVSLVLGAMLVCSLAGLTWTVV |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Interacts with DUOX1, DUOX2 and CYBA.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 681-737 | Sushi | ||||
Sequence: DACGFPDKVENGGFLLCDESGRRVLVFSCHHGFQLQGPEQVTCTRHGWDSQPPVCRD | ||||||
Domain | 737-780 | EGF-like | ||||
Sequence: DINECEDEVDPPCHASARCKNTKGSFQCECSDPHVPGEDGRTCV |
Sequence similarities
Belongs to the prostaglandin G/H synthase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length870
- Mass (Da)94,829
- Last updated2024-05-29 v2
- Checksum0035FC7087EF70B8
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3Q1M790 | A0A3Q1M790_BOVIN | TPO | 927 | ||
A0A3Q1LK39 | A0A3Q1LK39_BOVIN | TPO | 826 | ||
A0A3Q1NAI2 | A0A3Q1NAI2_BOVIN | TPO | 755 |
Keywords
- Technical term