A0A3Q1M2J4 · A0A3Q1M2J4_BOVIN

  • Protein
    Adenylosuccinate synthetase
  • Gene
    ADSS1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site42-48GTP (UniProtKB | ChEBI)
Active site43Proton acceptor
Binding site43Mg2+ (UniProtKB | ChEBI)
Binding site43-46IMP (UniProtKB | ChEBI)
Binding site68-71IMP (UniProtKB | ChEBI)
Binding site70Mg2+ (UniProtKB | ChEBI)
Binding site70-72GTP (UniProtKB | ChEBI)
Active site71Proton donor
Binding site220IMP (UniProtKB | ChEBI)
Binding site235IMP (UniProtKB | ChEBI)
Binding site295-301substrate
Binding site299IMP (UniProtKB | ChEBI)
Binding site301GTP (UniProtKB | ChEBI)
Binding site327-329GTP (UniProtKB | ChEBI)
Binding site409-411GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • Name
      ADSS1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1M2J4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-25Disordered

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    421
  • Mass (Da)
    46,276
  • Last updated
    2019-04-10 v1
  • Checksum
    238A747CD04C972F
MSGTRASNDRPPSAGGVKRGRLQHEAATTGSRVTVVLGAQWGDEGKGKVVDLLATDADVVSRCQGGNNAGHTVVVDGKEYDFHLLPSGIINPKAVSFIGNGVVVHLPGLFEEAEKNEKKGLKDWEKRLVISDRAHLVFDFHQAVDGLQEVQRQAQEGKKFKNLARQHQSMFPSLEVDVEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGEVYGVVKAYTTRVGIGAFPTEQINEIGDLLQSRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDALDEIKVGVAYKLGGKRIPYFPANQEILQKVEVEYETLPGWKADTTGARKWEDLPPQAQSYIRFVENHVGVAVKWVGVGKSRDSMIQLF

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAF6ZFA7A0AAF6ZFA7_BOVINADSS1472
A0AAA9SPF0A0AAA9SPF0_BOVINADSS1453
A0AAA9RUG8A0AAA9RUG8_BOVINADSS1444

Keywords

Genome annotation databases

Similar Proteins

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