A0A3Q1LSD1 · A0A3Q1LSD1_BOVIN

  • Protein
    Nitric oxide synthase
  • Gene
    NOS3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (UniProtKB | Rhea| CHEBI:59560 )

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN.
heme b (UniProtKB | Rhea| CHEBI:60344 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site197Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular ComponentGolgi apparatus
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functionactin monomer binding
Molecular Functionarginine binding
Molecular Functioncalmodulin binding
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Molecular Functionnitric-oxide synthase activity
Molecular Functiontetrahydrobiopterin binding
Biological Processarginine catabolic process
Biological Processendothelial cell migration
Biological Processnegative regulation of blood pressure
Biological Processnitric oxide biosynthetic process
Biological Processnitric oxide mediated signal transduction
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of blood vessel endothelial cell migration
Biological Processregulation of systemic arterial blood pressure by endothelin
Biological Processremoval of superoxide radicals
Biological Processresponse to fluid shear stress
Biological Processresponse to hormone
Biological Processresponse to lipopolysaccharide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nitric oxide synthase
  • EC number

Gene names

    • Name
      NOS3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1LSD1

Proteomes

Organism-specific databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-84Disordered
Compositional bias36-53Pro residues
Domain533-716Flavodoxin-like
Domain769-1015FAD-binding FR-type
Region831-858Disordered

Sequence similarities

Belongs to the NOS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,216
  • Mass (Da)
    134,956
  • Last updated
    2024-05-29 v2
  • Checksum
    5C9537C9E4280FD7
MGERLRALGRTESTGQPGPPSPPADPSSHWPSTPKLSLQPRPPAGPPCSHHPPPGQRSLGTRTSPAPNSPTLTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPDPWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKAAAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRATILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPGGPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGIAPFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFSREPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGPDTPGP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F1MY54F1MY54_BOVINNOS31205
A0AAA9SAA9A0AAA9SAA9_BOVINNOS31188

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias36-53Pro residues

Keywords

Genome annotation databases

Similar Proteins

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