A0A3Q1LQX6 · A0A3Q1LQX6_BOVIN

  • Protein
    Tropomyosin alpha-1 chain
  • Gene
    TPM1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoskeleton
Molecular Functionactin binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tropomyosin alpha-1 chain
  • Alternative names
    • Alpha-tropomyosin
    • Tropomyosin-1

Gene names

    • Name
      TPM1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1LQX6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain. Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG. Interacts (via N-terminus) with LMOD2 (via N-terminus) and TMOD1 (via N-terminus).

Family & Domains

Features

Showing features for region, coiled coil.

TypeIDPosition(s)Description
Region88-173Disordered
Region186-214Disordered
Coiled coil216-446

Sequence similarities

Belongs to the tropomyosin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    457
  • Mass (Da)
    49,262
  • Last updated
    2024-05-29 v2
  • Checksum
    7B7E07410D251DE0
MSLEGRRVAGLGSGVLGFFTVPLGTHLSPKPLARLLSLLGRDLAVRSGALPPPVGGTVAPCSQIRYSGFSAAPGRGAGSPSNILGAVGPRSPAHLVPPQRAPRPSAGQPRARAVPPATGEFPGSAARDPPRPLGPPPALAHPLAVRLSFPGGRDFRAEPGPQGAPPSRAAAWAGRAVGRSAAAAAAAGAQQPASPTAARPLAGPPPLGAMAGSSSLEAVRRKIRSLQEQADAAEERAGSLQRELDYERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1LFZ6A0A3Q1LFZ6_BOVINTPM1457
A0AAF6ZFK7A0AAF6ZFK7_BOVINTPM1306
A0AAA9U1R4A0AAA9U1R4_BOVINTPM1316
A0AAA9RSQ1A0AAA9RSQ1_BOVINTPM1364
A0A3Q1N0N4A0A3Q1N0N4_BOVINTPM1457
A0AAA9TTT0A0AAA9TTT0_BOVINTPM1316
A0A3Q1M1V8A0A3Q1M1V8_BOVINTPM1457
A0A3Q1LPQ6A0A3Q1LPQ6_BOVINTPM1326
A0A3Q1M5C0A0A3Q1M5C0_BOVINTPM1454

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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