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A0A3Q1LMA1 · A0A3Q1LMA1_BOVIN

  • Protein
    tRNA-intron lyase
  • Gene
    TSEN2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Catalytic activity

  • pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.
    EC:4.6.1.16 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

152850100150200250300350400450500
TypeIDPosition(s)Description
Active site432
Active site440
Active site479

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponenttRNA-intron endonuclease complex
Molecular Functionnucleic acid binding
Molecular FunctiontRNA-intron endonuclease activity
Biological ProcesstRNA-type intron splice site recognition and cleavage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-intron lyase
  • EC number
  • Alternative names
    • tRNA-intron endonuclease Sen2

Gene names

    • Name
      TSEN2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1LMA1

Proteomes

Organism-specific databases

Subcellular Location

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region206-315Disordered
Compositional bias226-242Basic and acidic residues
Domain348-392tRNA intron endonuclease N-terminal
Domain402-486tRNA intron endonuclease catalytic

Sequence similarities

Belongs to the tRNA-intron endonuclease family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    528
  • Mass (Da)
    60,107
  • Last updated
    2019-04-10 v1
  • MD5 Checksum
    C8EACE0A4C7A36BAB1214D0C3C5B4F12
MAEAVFRPPKRKRRVHDSYESPLPIPCGQDCGPEKDFRIFRAEMINSHVIVRGLEDMEQLYGKKWWRGSQSFWSQQEGEEEYQFWAHRNPRRFLCLVDLAPGPRVRRTPCLHLPFTFSSPGRTESITPETDEGYFGKGILSRSRPNFTISDPKLVAKWKDMKLDLPVITSKKYQRSVEWAAELLRRQGRDESMVRSVLEGYTKPLEHPHLKMMEEVPLGDEPNSEVVSKSEGRADREKLSAVNGVEGKSCDLEDSSERSNSPQEGPGPEPRTPDGSGEHVAEIPAPLPHGHWDALLLPSGGQPGDSSQRAGLVPAGERGPEHVLVEEAVCAGSEEVPAGDVLPQKRLVCRRNPFRIFEYLQLSLEEAFFLVYALGCLSIYYEKEPLTIMKLWNAFSTVQPTFRTTYMAYHHFRSKGWVPKPGLKYGTDLLLYRKGPPFYHASYSVIVELVDDRFQGAPRRPLSWRSLAALSRVSVSVSKELMLCYLIKPSTMTDKDMESPECMKQIKVQEVILSRWVSSRERSDQDEL

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3S5ZPE3A0A3S5ZPE3_BOVINTSEN2891
A0AAF6ZF59A0AAF6ZF59_BOVINTSEN2834
A0AAF6ZER6A0AAF6ZER6_BOVINTSEN2872
A0AAA9T921A0AAA9T921_BOVINTSEN2891
A0A3Q1N8C3A0A3Q1N8C3_BOVINTSEN2558
A0AAA9TJY4A0AAA9TJY4_BOVINTSEN2889
A0AAF7A081A0AAF7A081_BOVINTSEN2865
A0AAF6YI46A0AAF6YI46_BOVINTSEN2846
A0A3S5ZPE2A0A3S5ZPE2_BOVINTSEN2550

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias226-242Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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