A0A3Q1LLQ8 · A0A3Q1LLQ8_BOVIN

  • Protein
    Voltage-dependent T-type calcium channel subunit alpha
  • Gene
    CACNA1I
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Features

Showing features for binding site.

117772004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
Binding site342Ca2+ (UniProtKB | ChEBI)
Binding site835Ca2+ (UniProtKB | ChEBI)
Binding site1296Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionmetal ion binding
Molecular Functionvoltage-gated calcium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent T-type calcium channel subunit alpha

Gene names

    • Name
      CACNA1I

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A3Q1LLQ8

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane78-97Helical
Transmembrane117-137Helical
Transmembrane204-228Helical
Transmembrane330-351Helical
Transmembrane357-382Helical
Transmembrane776-798Helical
Transmembrane854-876Helical
Transmembrane1125-1146Helical
Transmembrane1158-1184Helical
Transmembrane1222-1244Helical
Transmembrane1323-1347Helical
Transmembrane1407-1424Helical
Transmembrane1444-1463Helical
Transmembrane1527-1554Helical
Transmembrane1629-1650Helical

Keywords

  • Cellular component

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-47Disordered
Compositional bias24-42Pro residues
Domain81-393Ion transport
Region450-491Disordered
Region549-604Disordered
Compositional bias577-594Polar residues
Region610-629Disordered
Domain654-881Ion transport
Region907-939Disordered
Compositional bias923-939Polar residues
Region958-988Disordered
Domain1085-1357Ion transport
Domain1407-1660Ion transport
Region1676-1708Disordered
Region1739-1761Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,777
  • Mass (Da)
    198,079
  • Last updated
    2019-04-10 v1
  • Checksum
    5BB0EA9F8D7D2A4D
MAENSPPPPSPTAARVAEPGVTEQPGPQSPPPSPPGPEEPLDGVDPEVPHPDLAPVAFFCLRQTTSPRNWCIKMVCNPYPFMLVILLNCVTLGMYQPCDDMDCLSERCKILQVFDDFIFVFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALRSRRQAAGMPGSATPGPRAKEPRHYSKSRGLQGAPPRPGVSPAGDSDTAVAKVLKYLSLVFSSVAQSCLTLRDPMDCSTPGLPVHHQLPELVQTHVQVVGDAIQPSYPLSSPSPPAFNLSHCPRCQHESDRRPSGQGSSSDSGQEGSGSGDAVGSEDEVGADVARTSEDGASLELGKEDEEGPADGAARLCEDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHQQPEELTNILEICNVVFTSMFALEMLLKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEVTVALVEEAPLWGLYETGGGGGLDRGGPQFKHLAGNGSPEEEPRASSQSSSRSSYYGPWGRSGAWASRRSSWNSLKHKQPSAEHESLLSAERGGARGCEGARDEGPLRTADSVDLAELVPAVGTHSRDCNGRMPSIDGWRRAALGSTDLPDPAAFSCQTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVPNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRTQMPKAQRLPYYATYCPTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELELAHGLGPSPRPPASAPGAPAPAHGPGGAAGEGDPEGRPCTGWTCHLCSDLLPSLTTALCLSGGPLPHRSPRGDPRWPALPAGAAGRDGGLLPELRQVLVHPAWR

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1MCM6A0A3Q1MCM6_BOVINCACNA1I2186
A0A3Q1LL52A0A3Q1LL52_BOVINCACNA1I1738
A0A3Q1N5J4A0A3Q1N5J4_BOVINCACNA1I1745
A0A3Q1MXV9A0A3Q1MXV9_BOVINCACNA1I1789
G3MWH6G3MWH6_BOVINCACNA1I1850
G3N292G3N292_BOVINCACNA1I1836
G3N034G3N034_BOVINCACNA1I1727
A0A3Q1MJ23A0A3Q1MJ23_BOVINCACNA1I1921
A0A3Q1MMH5A0A3Q1MMH5_BOVINCACNA1I2218

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias24-42Pro residues
Compositional bias577-594Polar residues
Compositional bias923-939Polar residues

Keywords

Genome annotation databases

Similar Proteins

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