A0A3Q1LLQ8 · A0A3Q1LLQ8_BOVIN
- ProteinVoltage-dependent T-type calcium channel subunit alpha
- GeneCACNA1I
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1777 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 342 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 835 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 1296 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | metal ion binding | |
Molecular Function | voltage-gated calcium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent T-type calcium channel subunit alpha
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A3Q1LLQ8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 78-97 | Helical | |||
Transmembrane | 117-137 | Helical | |||
Transmembrane | 204-228 | Helical | |||
Transmembrane | 330-351 | Helical | |||
Transmembrane | 357-382 | Helical | |||
Transmembrane | 776-798 | Helical | |||
Transmembrane | 854-876 | Helical | |||
Transmembrane | 1125-1146 | Helical | |||
Transmembrane | 1158-1184 | Helical | |||
Transmembrane | 1222-1244 | Helical | |||
Transmembrane | 1323-1347 | Helical | |||
Transmembrane | 1407-1424 | Helical | |||
Transmembrane | 1444-1463 | Helical | |||
Transmembrane | 1527-1554 | Helical | |||
Transmembrane | 1629-1650 | Helical | |||
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-47 | Disordered | |||
Compositional bias | 24-42 | Pro residues | |||
Domain | 81-393 | Ion transport | |||
Region | 450-491 | Disordered | |||
Region | 549-604 | Disordered | |||
Compositional bias | 577-594 | Polar residues | |||
Region | 610-629 | Disordered | |||
Domain | 654-881 | Ion transport | |||
Region | 907-939 | Disordered | |||
Compositional bias | 923-939 | Polar residues | |||
Region | 958-988 | Disordered | |||
Domain | 1085-1357 | Ion transport | |||
Domain | 1407-1660 | Ion transport | |||
Region | 1676-1708 | Disordered | |||
Region | 1739-1761 | Disordered | |||
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,777
- Mass (Da)198,079
- Last updated2019-04-10 v1
- Checksum5BB0EA9F8D7D2A4D
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3Q1MCM6 | A0A3Q1MCM6_BOVIN | CACNA1I | 2186 | ||
A0A3Q1LL52 | A0A3Q1LL52_BOVIN | CACNA1I | 1738 | ||
A0A3Q1N5J4 | A0A3Q1N5J4_BOVIN | CACNA1I | 1745 | ||
A0A3Q1MXV9 | A0A3Q1MXV9_BOVIN | CACNA1I | 1789 | ||
G3MWH6 | G3MWH6_BOVIN | CACNA1I | 1850 | ||
G3N292 | G3N292_BOVIN | CACNA1I | 1836 | ||
G3N034 | G3N034_BOVIN | CACNA1I | 1727 | ||
A0A3Q1MJ23 | A0A3Q1MJ23_BOVIN | CACNA1I | 1921 | ||
A0A3Q1MMH5 | A0A3Q1MMH5_BOVIN | CACNA1I | 2218 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 24-42 | Pro residues | |||
Compositional bias | 577-594 | Polar residues | |||
Compositional bias | 923-939 | Polar residues | |||
Keywords
- Technical term