A0A3Q1LKY2 · A0A3Q1LKY2_BOVIN
- ProteinInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- GenePPIP5K2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1088 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Catalytic activity
- 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADPThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | diphosphoinositol-pentakisphosphate kinase activity | |
Molecular Function | inositol heptakisphosphate kinase activity | |
Molecular Function | inositol hexakisphosphate 1-kinase activity | |
Molecular Function | inositol hexakisphosphate 3-kinase activity | |
Molecular Function | inositol hexakisphosphate 5-kinase activity | |
Molecular Function | inositol-1,3,4,5,6-pentakisphosphate kinase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A3Q1LKY2
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 50-139 | VIP1 N-terminal | ||||
Sequence: IVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEDVILNEPVENWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQD | ||||||
Region | 910-946 | Disordered | ||||
Sequence: KNLPSGYGYRPASRENEGRRAFKIDSDDEPHTSKKDE | ||||||
Compositional bias | 922-946 | Basic and acidic residues | ||||
Sequence: SRENEGRRAFKIDSDDEPHTSKKDE | ||||||
Region | 1040-1088 | Disordered | ||||
Sequence: PSSEVPRKTPETSPSGPSNTAVPNTSSRKKGVTSKTEMHEHKKNTSKKK | ||||||
Compositional bias | 1041-1070 | Polar residues | ||||
Sequence: SSEVPRKTPETSPSGPSNTAVPNTSSRKKG |
Sequence similarities
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,088
- Mass (Da)124,016
- Last updated2024-05-29 v2
- Checksum4F47E2A7C89B7147
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3Q1M2A3 | A0A3Q1M2A3_BOVIN | PPIP5K2 | 1286 | ||
A0A3Q1N5J8 | A0A3Q1N5J8_BOVIN | PPIP5K2 | 1194 | ||
A0A3Q1N807 | A0A3Q1N807_BOVIN | PPIP5K2 | 1027 | ||
A0AAA9TQU1 | A0AAA9TQU1_BOVIN | PPIP5K2 | 1057 | ||
F1MNG6 | F1MNG6_BOVIN | PPIP5K2 | 1231 | ||
A0A3Q1M0A9 | A0A3Q1M0A9_BOVIN | PPIP5K2 | 1249 | ||
A0A3Q1M5G6 | A0A3Q1M5G6_BOVIN | PPIP5K2 | 1188 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 922-946 | Basic and acidic residues | ||||
Sequence: SRENEGRRAFKIDSDDEPHTSKKDE | ||||||
Compositional bias | 1041-1070 | Polar residues | ||||
Sequence: SSEVPRKTPETSPSGPSNTAVPNTSSRKKG |
Keywords
- Technical term