A0A3Q1LJG6 · A0A3Q1LJG6_BOVIN
- Proteinaldehyde oxidase
- GeneAOX1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1342 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- H2O + O2 + retinal = H+ + H2O2 + retinoate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
Note: Binds 2 [2Fe-2S] clusters.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 47 | [2Fe-2S] cluster 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 52 | [2Fe-2S] cluster 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 55 | [2Fe-2S] cluster 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 77 | [2Fe-2S] cluster 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 117 | [2Fe-2S] cluster 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 120 | [2Fe-2S] cluster 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 152 | [2Fe-2S] cluster 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 154 | [2Fe-2S] cluster 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 267-274 | FAD (UniProtKB | ChEBI) | ||||
Sequence: VVMGNTSV | ||||||
Binding site | 370 | FAD (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 414 | FAD (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 432 | FAD (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 780 | Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 811 | Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 925 | Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 927 | substrate | ||||
Sequence: F | ||||||
Binding site | 1092 | Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Active site | 1274 | Proton acceptor | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | aldehyde oxidase activity | |
Molecular Function | FAD binding | |
Molecular Function | iron ion binding | |
Molecular Function | molybdopterin cofactor binding | |
Molecular Function | NAD binding | |
Molecular Function | protein homodimerization activity | |
Biological Process | lipid metabolic process | |
Biological Process | xenobiotic metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namealdehyde oxidase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A3Q1LJG6
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-95 | 2Fe-2S ferredoxin-type | ||||
Sequence: LDYTLKRDDLYITEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPITKKIRHYPANACLTPICSLYGAAVTTVEGI | ||||||
Domain | 239-424 | FAD-binding PCMH-type | ||||
Sequence: FGSDRMTWISPVTLKELLEAKVKYPQAPVVMGNTSVGPDMKFKGIFHPVIISPDRIEELSVVNYTDNGLTLGAAVSLAEVKDILANVTRKLPEEKTQMYHALLKHLETLAGPQIRNMASLGGHIVSRHPDSDLNPLLAVGNCTLNLLSKEGRRQIPLNEQFLRKCPSADLKPEEILISVNIPYSRK |
Sequence similarities
Belongs to the xanthine dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,342
- Mass (Da)147,856
- Last updated2024-05-29 v2
- Checksum57F8E59494EFAC38
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9T2X8 | A0AAA9T2X8_BOVIN | AOX1 | 1308 | ||
F1MRY9 | F1MRY9_BOVIN | AOX1 | 1339 | ||
A0AAA9TN84 | A0AAA9TN84_BOVIN | AOX1 | 1308 | ||
A0AAA9S924 | A0AAA9S924_BOVIN | AOX1 | 1271 |
Keywords
- Technical term