A0A3Q0J3B3 · A0A3Q0J3B3_DIACI

Function

Catalytic activity

  • Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
    EC:3.1.11.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.

Features

Showing features for binding site, active site, site.

110561002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site776Mg2+ 1 (UniProtKB | ChEBI)
Binding site804Mg2+ 1 (UniProtKB | ChEBI)
Active site912
Active site951Proton donor/acceptor
Binding site951Mg2+ 1 (UniProtKB | ChEBI)
Binding site953Mg2+ 1 (UniProtKB | ChEBI)
Site953Transition state stabilizer
Site1021Important for catalytic activity
Binding site1046Mg2+ 1 (UniProtKB | ChEBI)
Active site1047Proton acceptor
Binding site1047Mg2+ 1 (UniProtKB | ChEBI)
Site1047Interaction with DNA substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionmetal ion binding
Molecular Functionphosphoric diester hydrolase activity
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    exodeoxyribonuclease III
  • EC number

Gene names

    • Name
      LOC108251834

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Sternorrhyncha > Psylloidea > Psyllidae > Diaphorininae > Diaphorina

Accessions

  • Primary accession
    A0A3Q0J3B3

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_501815290223-1056exodeoxyribonuclease III

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region307-326Disordered
Region421-518Disordered
Compositional bias480-501Polar residues
Region539-571Disordered
Compositional bias554-571Polar residues
Domain773-1047Endonuclease/exonuclease/phosphatase

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,056
  • Mass (Da)
    120,817
  • Last updated
    2019-02-13 v1
  • Checksum
    EA8491196BCB1610
MDLFRLGNEVIVLVLDLLCVYCTLVSDNSSVPCLIQDNGAILSSKPPFPSLKYSYSTFRWNETRPTTMFVTINRRHEYDFLYSDRECQVVRKKRVSPSREMHLKDILATFDSEDGAIVVDASRRDRKELKEPTLPEDLFDDLECESLHVSELKDENDENIGAQSQVIHDSLFKHRNRTESHSPEPLKMTNPREDYDFFSDFNVKPIRKTSANKSVKADDLKNVLNLFASEDGGYVPVLKKSVEISQEKEPTLPAILMGNSELHVSEMEENNDDSNIKLHREVKSDVNEDQESNIKIVRDLDSEVINSEQTVDRTESSEDKYSKSQHGDLNDIYFPSNLYHKKTFKTTAGSSENILLKGLLMNRKSTQPRHSISTSKNRSPTQNEIDMIVENFISVQRKFSLNTVRPVTHFLNVSNEESYEKYTFRKRKGKTKTTRIKTTKYSDKSTKRRGRPKKTTTPSGGIISSPSKNTRKHDKKYTTNSESIQTSVSNIRDSTSRNLKTKSVNIEDKSESASTATLKTIGKEDKDFISRPVKSSRVSTKIQLDHSVKKSQKQGLTKYESQPSSTSTSTDVLPAHKMSLAPERKIAQFNNRNKLVLLHTKTTHVKTVPSENVQNTKGKFELLKEIKFERTGSEDTSEDVEESGFFTVEPIPDSNLYNEWEYRPPKRKVKTSTFSLKSLKNLDDKLSYIREVCGEHMPVNVTKKASRKNVFSFKLNEIHVGTGKIENRLGCDSSNETSYAEVEEVPIIDFNDPFRILEHKRRQDQYPWNFKIGSWNVNGIRAWSQKDGFSFMRQHDLNVFCIQEIRCPLEKLPECPEGYHAFWFPGTRQGYAGVAVLSKTKPVRVTHGFSMKVGGVVHTHGFNRGSNEHGSDMESGPSHPELTTIQYADASGIDDGRVMTVEYEQFYLVNVYAPAAKEDLSMLSVKLLWNSFLRGHLKSLNEIKPVVLAGDLNVAHNHIDVALPLTNLGKSGFTIQERNYFSNFLDLGFLDVHRHLYPNHRIYTYWPYYDRPSKMKGWRLDYFLISKQLKSHLSDLEIHGDVEGSDHAPQILYLNL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias480-501Polar residues
Compositional bias554-571Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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