A0A3P9LME2 · A0A3P9LME2_ORYLA

Function

Catalytic activity

  • 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
    This reaction proceeds in the backward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • Hydrolyzes glycerol monoesters of long-chain fatty acids.
    EC:3.1.1.23 (UniProtKB | ENZYME | Rhea)
  • a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a monoacylglycerol + H2O = glycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site428

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular Componentlipid droplet
Molecular Functiondiacylglycerol lipase activity
Molecular Functionhormone-sensitive lipase activity
Molecular Functionmonoacylglycerol lipase activity
Molecular Functiontriacylglycerol lipase activity
Biological Processcholesterol metabolic process
Biological Processtriglyceride catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hormone-sensitive lipase
  • EC number
  • Alternative names
    • Monoacylglycerol lipase LIPE
    • Retinyl ester hydrolase

Organism names

  • Taxonomic identifier
  • Strains
    • Hd-rR
    • HNI
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    A0A3P9LME2

Proteomes

Subcellular Location

Cell membrane
Cytoplasm, cytosol
Lipid droplet
Membrane, caveola

Keywords

Interaction

Subunit

Monomer and homodimer. Interacts with CAVIN1 in the adipocyte cytoplasm. Interacts with PLIN5.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain6-317Hormone-sensitive lipase N-terminal
Domain350-497Alpha/beta hydrolase fold-3
Domain578-654Alpha/beta hydrolase fold-3
Region681-713Disordered

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    713
  • Mass (Da)
    78,550
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    D0EADF3BF3EBD22112732AAFBA7EA32E
MDTKAVFAALYSVCEENATFFSAGGKVSQADSAKRLVESMKLIQEHARSLEPVISGFAAIYHHFDFDPLIPANGYRSLVKVVRCCLLHIIHKGRYIAANRRSIFFRAAHNAGEMEAYCSALCQLRALLYLAQRMLHDNSHGNLFFQDESGLSESFIREYASMHKGCFYGRCLGFQFTPAIRPCLQTIAIGLVAFGENYKRHQSGIGVAASSFFTSGKYAIDPELRGTEFERITQNLDVHFWKTFWNITETEVLSSLASMTSTQVKVNRALSVPPVAFDLPLAANHRASATIAPPSAHIGIAPIQMRLISYDLREGQDSETLLSMSRSEGGAISLSLGLKTKRLPSSPFLLIHFHGGGFVAQTSKSHEPYLKSWSQDLGVPILSVDYSLAPEAPFPRALEECFYAYCWALRNHHLLGWTGEKVCLAGDSAGGNLCVTTCMRAAAFGVRMPDGVVAAYPATLLTAYASPSRLLTLMDPLLPLSVLSRCLSAYAGSEPQTEKQVERVSTLSLVKRDTALFLRDFRQGASNWIHSLLDSNRETDPNISRDLSSVAIPPPAAEEGIELQHPREFPLGFEPLRSDQFAEMKLQSSPVFKDPFCSPLLAPDSMLKGLPPIHIVACALDPMLDDSVMFAKRLRSVNQPVTLCVVDDLPHGFLSLSQLSKETKEAANVCVERIRAVFLQDTPPEPRKHPPASCHAPHVAVPPPKKNKENQTF

Genome annotation databases

Similar Proteins

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