A0A3P9J5X1 · A0A3P9J5X1_ORYLA

Function

function

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

Catalytic activity

Activity regulation

Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.

Features

Showing features for binding site, active site, site.

110681002003004005006007008009001,000
Type
IDPosition(s)Description
Binding site555Mg2+ (UniProtKB | ChEBI)
Binding site582-590ATP (UniProtKB | ChEBI)
Binding site583-590ATP (UniProtKB | ChEBI)
Binding site610ATP (UniProtKB | ChEBI)
Binding site658-664ATP (UniProtKB | ChEBI)
Active site799Proton acceptor
Binding site803ATP (UniProtKB | ChEBI)
Binding site804Mg2+ (UniProtKB | ChEBI)
Binding site817Mg2+ (UniProtKB | ChEBI)
Site943Important for interaction with phosphotyrosine-binding proteins

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionplatelet-derived growth factor alpha-receptor activity
Biological Processchemotaxis
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Platelet-derived growth factor receptor alpha
  • EC number
  • Short names
    PDGF-R-alpha
    ; PDGFR-alpha
  • Alternative names
    • Alpha platelet-derived growth factor receptor
    • Alpha-type platelet-derived growth factor receptor

Organism names

  • Taxonomic identifier
  • Strains
    • Hd-rR
    • HSOK
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    A0A3P9J5X1

Proteomes

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane508-532Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_501802612922-1068Platelet-derived growth factor receptor alpha
Disulfide bond53↔98
Disulfide bond146↔187
Disulfide bond230↔279
Disulfide bond419↔485

Keywords

Interaction

Subunit

Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain207-297Ig-like
Domain308-389Ig-like
Domain398-501Ig-like
Domain576-934Protein kinase
Region739-762Disordered
Region980-1042Disordered
Compositional bias1008-1023Basic and acidic residues
Compositional bias1024-1040Polar residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,068
  • Mass (Da)
    120,061
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    DF632BA914AC52E14F111ED4411DB208
MLPHLFDSCCLILSCLIVVLSLKAMFPPSMAPVLLPDKEELLVPLHTPFTMTCHGQAKLEWDTPYNVPVRVQQDHSGLFVTTIMVDWAEAYHTGSYKCFYSGSNTEDSKSQSIYVFVPDPDVPFVPSLKPFSNHVLSDHEEMEIQCRVSDPSANVTLINLETQQPVPSVYDSKRGALGVFLAGTYVCKALINGHEYYSEEYIVHGWPALHVELKAKRTALLVGETITVTCLARGPEILEDNWKYPGKAVRTILHKQNQEILYTLTIPQASVKDSGSYSCSIVDIANNEIQTKEQEIQVFAGEFVSIDPEFGEHESAELDEVREFRANVHSFPNARVTWIKDGIPLSDVTAEISTSLRQTSETSYMSVLTLIRAKGEDSGNYTMQVENGNQILFIHLVPAVIVDLMDIHHGSAIGQSVVCITRGRPTPAVEWFICKSIKHCGNNSSFWVPLATNSTDIVFDSHFEGNNLESQVVFGHLESTLAVRCLARNEMATVSREVKLVSSPHPELTVAAAILVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESVSPDGHEYIYVDPMQLPYDSRWEFPRDRLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRENFLSLSPEKNRKEMDIFGINPADESSRSYVILSFESKGDYMDMKQADNTQYVPMLEMNNASKYSDVQRSNYDHPPSQKGSSGMTMENLLSDDTTEGLTTTDLLSFTYQVAKGMEFLSSKNCVHRDLAARNVLLSQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMVVDSSFYNKIKSGYRMSKPEHAPQDIYEMMIKCWNSDPEKRPSFMGLSETVALLLPSSYRRHYERVNRDFLKSDHPAVTRVCMENDTDYVDIPYKNQGKLKERESGFDEQRLSSDSGYIIPLPDLDPLSDEEYGKRNRHSSQTSEESAIETGSSSSTYPKREGETLEDITLLDEMCLDCSDLVEDSFL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1008-1023Basic and acidic residues
Compositional bias1024-1040Polar residues

Genome annotation databases

Similar Proteins

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