A0A3P9DLE2 · A0A3P9DLE2_9CICH
- ProteinHormone-sensitive lipase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids692 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2OThis reaction proceeds in the backward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+This reaction proceeds in the forward direction.
- 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+This reaction proceeds in the forward direction.
- 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+This reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+This reaction proceeds in the forward direction.
- all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoateThis reaction proceeds in the forward direction.
- cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+This reaction proceeds in the forward direction.
Pathway
Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 427 | |||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | caveola | |
Cellular Component | cytosol | |
Cellular Component | lipid droplet | |
Molecular Function | acylglycerol lipase activity | |
Molecular Function | hormone-sensitive lipase activity | |
Biological Process | cholesterol metabolic process | |
Biological Process | triglyceride catabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHormone-sensitive lipase
- EC number
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > African cichlids > Pseudocrenilabrinae > Haplochromini > Maylandia > Maylandia zebra complex
Accessions
- Primary accessionA0A3P9DLE2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-317 | Hormone-sensitive lipase N-terminal | ||||
Sequence: VFATLEKVCQDNISVFCGPSRLPHGTAVERLVTCVKQIQEHGRALEPVVTSFTAVYHHYDFDAQTPGNGYRTLVKVLEACLLHIIHKARYIASSYSNPFFRVDHNTSEMEAYCSALCQLRALLHLAQQLINDNDCGQLYSLQDKDLSRSFVQEYSSMHKACFYGRCLGFQYSPSIRPFLQTVVISMVSYGETYGKQQSGLGTAALSLLTSGKYVIDPELRGAEFERITQNLDMQFWKSFWNLTESGLLTGFNRIASKQVQVNFTMTVPPVTLRLPLASDPRLSVTVSPPIAHWGPGPVHMRLISYELREGQD | ||||||
Domain | 349-503 | Alpha/beta hydrolase fold-3 | ||||
Sequence: LIHFHGGGFVAQTSKSHENYLRSWSKELNVPVLSVDYSLSPEAPFPRALEECFYAYCWALNNCHLLGSTAERVCLAGDSAGGNLCITVSMKAISTGIRIPDGIMAAYPATLLTTDASPSRLLTLIDPLLPLGVLTKCINAYAGIDYQTVQPAMGS | ||||||
Region | 536-562 | Disordered | ||||
Sequence: RTSGRSLSRSSSQRQTETHMSNQASVP | ||||||
Domain | 594-655 | Alpha/beta hydrolase fold-3 | ||||
Sequence: KNPFVSPLLAPNSMLKGLPPVHIVASALDALLDDSVMFAKKLRDMGQPVSLTVAKDLPHGFL |
Sequence similarities
Belongs to the 'GDXG' lipolytic enzyme family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length692
- Mass (Da)76,473
- Last updated2019-02-13 v1
- ChecksumB91FA6E5D60EA437
Keywords
- Technical term