A0A3P9B138 · A0A3P9B138_9CICH
- ProteinFibroblast growth factor receptor
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids817 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 483-489 | ATP (UniProtKB | ChEBI) | |||
Binding site | 513 | ATP (UniProtKB | ChEBI) | |||
Binding site | 561-563 | ATP (UniProtKB | ChEBI) | |||
Binding site | 567 | ATP (UniProtKB | ChEBI) | |||
Active site | 622 | Proton acceptor | |||
Binding site | 626 | ATP (UniProtKB | ChEBI) | |||
Binding site | 640 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | fibroblast growth factor binding | |
Molecular Function | fibroblast growth factor receptor activity | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | positive regulation of kinase activity | |
Biological Process | positive regulation of MAPK cascade | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFibroblast growth factor receptor
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > African cichlids > Pseudocrenilabrinae > Haplochromini > Maylandia > Maylandia zebra complex
Accessions
- Primary accessionA0A3P9B138
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 381-401 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-41 | ||||
Chain | PRO_5018227582 | 42-817 | Fibroblast growth factor receptor | ||
Disulfide bond | 74↔123 | ||||
Disulfide bond | 186↔238 | ||||
Disulfide bond | 285↔348 | ||||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 51-140 | Ig-like | |||
Domain | 155-254 | Ig-like | |||
Domain | 263-352 | Ig-like | |||
Domain | 477-756 | Protein kinase | |||
Region | 781-817 | Disordered | |||
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length817
- Mass (Da)91,504
- Last updated2019-02-13 v1
- ChecksumC5D97EDE06C62DB1
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3P9B183 | A0A3P9B183_9CICH | 798 | |||
A0A3P9B1B1 | A0A3P9B1B1_9CICH | 817 |
Keywords
- Technical term