A0A3P8YG95 · A0A3P8YG95_ESOLU
- ProteinBroad substrate specificity ATP-binding cassette transporter ABCG2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids665 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- indoxyl sulfate(in) + ATP + H2O = indoxyl sulfate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- methotrexate(in) + ATP + H2O = methotrexate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- riboflavin(in) + ATP + H2O = riboflavin(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- urate(in) + ATP + H2O = urate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- dehydroepiandrosterone 3-sulfate(in) + ATP + H2O = dehydroepiandrosterone 3-sulfate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- estrone 3-sulfate(in) + ATP + H2O = estrone 3-sulfate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial membrane | |
Cellular Component | plasma membrane | |
Molecular Function | ABC-type transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | efflux transmembrane transporter activity | |
Molecular Function | riboflavin transmembrane transporter activity |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBroad substrate specificity ATP-binding cassette transporter ABCG2
- EC number
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Esociformes > Esocidae > Esox
Accessions
- Primary accessionA0A3P8YG95
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 410-430 | Helical | |||
Transmembrane | 493-513 | Helical | |||
Transmembrane | 519-541 | Helical | |||
Transmembrane | 553-581 | Helical | |||
Transmembrane | 634-656 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Homodimer; disulfide-linked. The minimal functional unit is a homodimer, but the major oligomeric form in plasma membrane is a homotetramer with possibility of higher order oligomerization up to homododecamers.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-46 | Disordered | |||
Domain | 59-296 | ABC transporter | |||
Sequence similarities
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length665
- Mass (Da)74,070
- Last updated2020-12-02 v2
- ChecksumD41F0AEC539EEF17
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6Q2WSN8 | A0A6Q2WSN8_ESOLU | 676 | |||
A0A6Q2XZE2 | A0A6Q2XZE2_ESOLU | 622 | |||
A0A6Q2XZI6 | A0A6Q2XZI6_ESOLU | 598 | |||
A0A6Q2ZMJ4 | A0A6Q2ZMJ4_ESOLU | 607 | |||
A0A6Q2ZNH7 | A0A6Q2ZNH7_ESOLU | 667 | |||
A0A6Q2WZS2 | A0A6Q2WZS2_ESOLU | 615 | |||
A0A6Q2ZAW2 | A0A6Q2ZAW2_ESOLU | 600 | |||
A0A6Q2WTE0 | A0A6Q2WTE0_ESOLU | 649 | |||
A0A6Q2Z7Y0 | A0A6Q2Z7Y0_ESOLU | 631 |
Keywords
- Technical term