A0A3P8U565 · A0A3P8U565_AMPPE

Function

function

Protein hedgehog N-product

The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

Protein hedgehog

The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.

Catalytic activity

Features

Showing features for binding site, site.

141750100150200250300350400
TypeIDPosition(s)Description
Binding site96Ca2+ 1 (UniProtKB | ChEBI)
Binding site97Ca2+ 2 (UniProtKB | ChEBI)
Binding site97Ca2+ 1 (UniProtKB | ChEBI)
Binding site102Ca2+ 1 (UniProtKB | ChEBI)
Binding site132Ca2+ 1 (UniProtKB | ChEBI)
Binding site133Ca2+ 2 (UniProtKB | ChEBI)
Binding site133Ca2+ 1 (UniProtKB | ChEBI)
Binding site136Ca2+ 2 (UniProtKB | ChEBI)
Binding site138Ca2+ 2 (UniProtKB | ChEBI)
Binding site147Zn2+ (UniProtKB | ChEBI)
Binding site154Zn2+ (UniProtKB | ChEBI)
Binding site189Zn2+ (UniProtKB | ChEBI)
Site204-205Cleavage; by autolysis
Site250Involved in cholesterol transfer
Site274Involved in auto-cleavage
Site277Essential for auto-cleavage

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentextracellular space
Cellular ComponentGolgi membrane
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionpatched binding
Molecular Functionpeptidase activity
Molecular Functiontransferase activity
Biological Processanimal organ development
Biological Processcell development
Biological Processcell fate specification
Biological Processcell-cell signaling
Biological Processcentral nervous system development
Biological Processintein-mediated protein splicing
Biological Processneuron differentiation
Biological Processpattern specification process
Biological Processprotein autoprocessing
Biological Processregulation of cell population proliferation
Biological Processregulation of developmental process
Biological Processregulation of gene expression
Biological Processsmoothened signaling pathway
Biological Processtissue development
Biological Processtube development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hedgehog protein

Organism names

Accessions

  • Primary accession
    A0A3P8U565

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
Membrane
; Lipid-anchor

Sonic hedgehog protein

Endoplasmic reticulum membrane
Golgi apparatus membrane

Protein hedgehog N-product

Cell membrane
; Lipid-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-30
ChainPRO_501807629731-417Hedgehog protein

Keywords

Interaction

Subunit

Multimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain203-309Hint
Domain313-357Hint

Sequence similarities

Belongs to the hedgehog family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    417
  • Mass (Da)
    47,075
  • Last updated
    2019-02-13 v1
  • Checksum
    44A3931B614AA46F
MDPPRQSKMVLMRAMLSTLLCLLLASASWGCGPGRGYGKRRHPKKLTPLALKQFIPNVAEKTLGASGKYEGKIIRNSERFKDLTPNYNPDIIFKDEENTNADRLMTQRCKDKLNSLAISVMNQWPGIKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDKSKYGMLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAVKSGGCFPGSSMVILAEGNTKQLKDLQVGDKVLTADQRGNLVPSDFLMFIDQDQQISREFHVLETDEPCHRLKMTPAHLVFVMNNSTNSSSIRAMFASNVKPGQWLLVVGNDQSEYLIPARVTRVYVEKYEGSYAPMTSHGTIIVDRVLASCYAVVEDHDLAHWVFTPVRLWHSFLSLFGMVKELSSVHQADGVHWYPELLYYVGSWLLDRSSFHPQS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3P8UEE7A0A3P8UEE7_AMPPE412

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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