A0A3P8SZL5 · A0A3P8SZL5_AMPPE
- ProteinHepatic triacylglycerol lipase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids496 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H+This reaction proceeds in the forward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H+ + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholineThis reaction proceeds in the forward direction.
- 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H+ + sn-glycero-3-phospho-L-serineThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H+ + hexadecanoate + sn-glycerol 3-phosphocholineThis reaction proceeds in the forward direction.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | high-density lipoprotein particle | |
Molecular Function | 1-acyl-2-lysophosphatidylserine acylhydrolase activity | |
Molecular Function | heparin binding | |
Molecular Function | lysophospholipase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylserine 1-acylhydrolase activity | |
Molecular Function | phospholipase A1 activity | |
Molecular Function | triglyceride lipase activity | |
Biological Process | lipid metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHepatic triacylglycerol lipase
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Pomacentridae > Amphiprion
Accessions
- Primary accessionA0A3P8SZL5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MLGVKILCCLLLTCHLSGG | ||||||
Chain | PRO_5018269106 | 20-496 | Hepatic triacylglycerol lipase | |||
Sequence: KKIKGERASVADIEQRIVLRVKEPYVSSSAFSLFLGGEDTCTLDPLQLHTLTSCGFNSSNPLIIITHGWSVDGMMESWVLRLASALKTNLVSVNVVLTDWLSLAHQHYPMAVQSTRTVGKDISHLLQTLQEQYQYPVKKVHLIGYSLGAHISGFAGSYLEGSEKIGRITGLDPAGPLFEGMSPTDRLSPDDAEFVDAIHTFTHERMGLSVGIKQAVAHFDFYPNGGDFQPGCDLQNIYEHITEYGLLGFEQTVKCAHERSVHLFIDSLLNKDKQSMAYRCSDNNAFVKGVCLDCRKNRCNTLGYDIKKVRTVTSKRLYLKTRSRMPYKLYHYQFRIQFINQVENIDPTLTVALTGTKEESGDVVITFNEKISGNTTFPFLITLDKDLGDLMLVKLHWEGLALWKNVWNRVQTIIPWGGKETKPLLTVGRISVKAGETQERTSFCAMTDDGQQIEVSQDKVFVRCKEDIPKQRRRKHN |
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 349-482 | PLAT | ||||
Sequence: YHYQFRIQFINQVENIDPTLTVALTGTKEESGDVVITFNEKISGNTTFPFLITLDKDLGDLMLVKLHWEGLALWKNVWNRVQTIIPWGGKETKPLLTVGRISVKAGETQERTSFCAMTDDGQQIEVSQDKVFVR |
Sequence similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length496
- Mass (Da)55,770
- Last updated2019-02-13 v1
- Checksum76781F646027793C
Keywords
- Technical term