A0A3P8S849 · A0A3P8S849_AMPPE
- ProteinZona pellucida sperm-binding protein 4
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids715 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | egg coat | |
Cellular Component | extracellular region | |
Cellular Component | plasma membrane | |
Molecular Function | acrosin binding | |
Molecular Function | structural constituent of egg coat | |
Biological Process | binding of sperm to zona pellucida | |
Biological Process | prevention of polyspermy |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameZona pellucida sperm-binding protein 4
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Pomacentridae > Amphiprion
Accessions
- Primary accessionA0A3P8S849
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 363↔389 | ||||
Disulfide bond | 373↔388 | ||||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-26 | Disordered | |||
Compositional bias | 12-26 | Pro residues | |||
Region | 40-72 | Disordered | |||
Compositional bias | 42-72 | Pro residues | |||
Region | 85-324 | Disordered | |||
Compositional bias | 86-120 | Pro residues | |||
Compositional bias | 133-160 | Pro residues | |||
Compositional bias | 161-175 | Polar residues | |||
Compositional bias | 177-232 | Pro residues | |||
Compositional bias | 252-277 | Polar residues | |||
Compositional bias | 278-317 | Pro residues | |||
Domain | 361-399 | P-type | |||
Domain | 404-685 | ZP | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length715
- Mass (Da)78,534
- Last updated2019-02-13 v1
- ChecksumE58A1C6EE6C40AA5
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3P8SAE2 | A0A3P8SAE2_AMPPE | 568 | |||
A0A3P8SAC7 | A0A3P8SAC7_AMPPE | 486 | |||
A0A3P8SAW6 | A0A3P8SAW6_AMPPE | 588 | |||
A0A3P8SAW7 | A0A3P8SAW7_AMPPE | 488 | |||
A0A3P8SBT3 | A0A3P8SBT3_AMPPE | 633 | |||
A0A3P8SA95 | A0A3P8SA95_AMPPE | 594 | |||
A0A3P8SA54 | A0A3P8SA54_AMPPE | 421 | |||
A0A3P8S8R1 | A0A3P8S8R1_AMPPE | 576 | |||
A0A3P8S8J2 | A0A3P8S8J2_AMPPE | 416 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 12-26 | Pro residues | |||
Compositional bias | 42-72 | Pro residues | |||
Compositional bias | 86-120 | Pro residues | |||
Compositional bias | 133-160 | Pro residues | |||
Compositional bias | 161-175 | Polar residues | |||
Compositional bias | 177-232 | Pro residues | |||
Compositional bias | 252-277 | Polar residues | |||
Compositional bias | 278-317 | Pro residues | |||
Keywords
- Technical term