A0A3P8S849 · A0A3P8S849_AMPPE

Function

function

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentegg coat
Cellular Componentextracellular region
Cellular Componentplasma membrane
Molecular Functionacrosin binding
Molecular Functionstructural constituent of egg coat
Biological Processbinding of sperm to zona pellucida
Biological Processprevention of polyspermy

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Zona pellucida sperm-binding protein 4
  • Alternative names
    • Zona pellucida glycoprotein 4
    • Zona pellucida protein B

Organism names

Accessions

  • Primary accession
    A0A3P8S849

Proteomes

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Zona pellucida

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond363↔389
Disulfide bond373↔388

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-26Disordered
Compositional bias12-26Pro residues
Region40-72Disordered
Compositional bias42-72Pro residues
Region85-324Disordered
Compositional bias86-120Pro residues
Compositional bias133-160Pro residues
Compositional bias161-175Polar residues
Compositional bias177-232Pro residues
Compositional bias252-277Polar residues
Compositional bias278-317Pro residues
Domain361-399P-type
Domain404-685ZP

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    715
  • Mass (Da)
    78,534
  • Last updated
    2019-02-13 v1
  • Checksum
    E58A1C6EE6C40AA5
MAQGGTLPQTLQVGQPPPPHPPYPQTIQVQYPALKVPLYSLTPQVEPPPPRRPCPHVPQVMPPPPPLPYPQTIQVQPLPLRLLYPETPQVKPPPPSPPYPQMIQVQPPPAPPPDPQMPQVQPPALQTALYPHMPQVKPPPLRPPFPKTIQMQPSPPPPLFSQTIQVQSLSSHPPYPQRAQVKPPPPHPPYPQTPQVQPHPPSPPYPQTPQVQPSPPKTPLHHQTPQVKPPLLRPPFLETIQMQPSPPPPLFSQTIQVQSLSSRPAYPQTAQVQPLPSHPSYAPTPQVQPPPPIIRPYPGTPHAQPPPPKPQLQNPNYPTFPQYPHGSVITRYPQTLPALQSSQNPQAPQPHPQKLQQTTFQSCEVAQSQRIPCGGSDISAAACESISCCSDGRQCYFGKAVTVQCTKDAKFIVVVAKDATLPNIDLEAISLLGGGQGCTHVDSNSQFAIYQFPVTACGSLVKEEPGVIIYENKMTCAYEVGVGPLGATTRDRHYEVLFQCRYIGTSVETLVVEVLPLQNPPLPVAGLGPISVKLRLANGQCSSKGCNEVDVAYSSFYSEADYPVRKVLRDPVYVDVQLLGKTDPLLVLTLGRCWATTSPEPHSLPQWDILIDGCPYRDDRYLSSLVPVDHASGFPSHHKHFIFKMFTFLDPSSMATQREMVYIHCSTAVCYAAPGTRCEPVCYRRKRDVKAVSQEKSEQRVVVSSGPVAMVSPQQ

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3P8SAE2A0A3P8SAE2_AMPPE568
A0A3P8SAC7A0A3P8SAC7_AMPPE486
A0A3P8SAW6A0A3P8SAW6_AMPPE588
A0A3P8SAW7A0A3P8SAW7_AMPPE488
A0A3P8SBT3A0A3P8SBT3_AMPPE633
A0A3P8SA95A0A3P8SA95_AMPPE594
A0A3P8SA54A0A3P8SA54_AMPPE421
A0A3P8S8R1A0A3P8S8R1_AMPPE576
A0A3P8S8J2A0A3P8S8J2_AMPPE416

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias12-26Pro residues
Compositional bias42-72Pro residues
Compositional bias86-120Pro residues
Compositional bias133-160Pro residues
Compositional bias161-175Polar residues
Compositional bias177-232Pro residues
Compositional bias252-277Polar residues
Compositional bias278-317Pro residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp