A0A3P8RQC8 · A0A3P8RQC8_AMPPE
- Proteinnon-specific serine/threonine protein kinase
- GeneEIF2AK4
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1459 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 397-405 | ATP (UniProtKB | ChEBI) | |||
Binding site | 420 | ATP (UniProtKB | ChEBI) | |||
Active site | 655 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | eukaryotic translation initiation factor 2alpha kinase activity | |
Molecular Function | histone H2AS1 kinase activity | |
Biological Process | DNA damage checkpoint signaling |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Pomacentridae > Amphiprion
Accessions
- Primary accessionA0A3P8RQC8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-67 | Disordered | |||
Compositional bias | 49-64 | Basic and acidic residues | |||
Domain | 94-338 | Protein kinase | |||
Domain | 391-810 | Protein kinase | |||
Region | 464-548 | Disordered | |||
Compositional bias | 475-498 | Basic and acidic residues | |||
Compositional bias | 512-531 | Polar residues | |||
Region | 561-593 | Disordered | |||
Region | 1316-1344 | Disordered | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,459
- Mass (Da)164,543
- Last updated2019-02-13 v1
- ChecksumADCBD1A463B5B75F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3P8RLV2 | A0A3P8RLV2_AMPPE | EIF2AK4 | 1396 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 49-64 | Basic and acidic residues | |||
Compositional bias | 475-498 | Basic and acidic residues | |||
Compositional bias | 512-531 | Polar residues | |||
Keywords
- Technical term