A0A3P8RM62 · A0A3P8RM62_AMPPE
- ProteinRho-associated protein kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1364 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]This reaction proceeds in the forward direction.
Cofactor
Activity regulation
Activated by RHOA binding. Inhibited by Y-27632.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | bleb | |
Cellular Component | centriole | |
Cellular Component | Golgi membrane | |
Cellular Component | lamellipodium | |
Cellular Component | plasma membrane | |
Cellular Component | ruffle | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | small GTPase binding | |
Biological Process | actin cytoskeleton organization | |
Biological Process | epicardial cell to mesenchymal cell transition | |
Biological Process | negative regulation of adherens junction organization | |
Biological Process | positive regulation of stress fiber assembly | |
Biological Process | Rho protein signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRho-associated protein kinase
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Pomacentridae > Amphiprion
Accessions
- Primary accessionA0A3P8RM62
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 76-338 | Protein kinase | ||||
Sequence: YEVVKVIGRGAFGEVQLVRHKATSKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSSWVVQLFFAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKAGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNALTFPDDSDISNDAKNLICAFLTDREVRLGRNGVDEIKRHPFF | ||||||
Domain | 341-409 | AGC-kinase C-terminal | ||||
Sequence: DQWTWENIRETAAPVVPELSSDIDTSNFDDIEEDRGEEETFPIPKAFVGNQLPFVGFTYYSNQHPLRSS | ||||||
Region | 407-429 | Disordered | ||||
Sequence: RSSTATKTSDKRSSSTKEDKSHL | ||||||
Domain | 476-560 | REM-1 | ||||
Sequence: NLRKSAEASVSLLEKDKIMLQHRFTEYQRKADQEAEKRRNLENEVSTLKEQLEDMKKISQNSQASNDKIAQLQSQLEEANDLLRA | ||||||
Region | 568-598 | Disordered | ||||
Sequence: LRKSHTEVAKSMSQLESLNRDLQERSRAADG | ||||||
Coiled coil | 752-898 | |||||
Sequence: LKQSVQKMEQLMKQKERLEDEVKILRIQVEQESSKRGLTQNELKSRMQEVDRLRCSEKQLKQEINTALESKRSLEFQLAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEERNRQVQEAHKRMQDLNSERDSLSAQ | ||||||
Coiled coil | 931-993 | |||||
Sequence: VTRHKQEIGEKESTITRLEESNKTLTKDVENLSKEKTELNEKLRTQEEEYAAQKEEIANTIKA | ||||||
Domain | 956-1022 | RhoBD | ||||
Sequence: TKDVENLSKEKTELNEKLRTQEEEYAAQKEEIANTIKANYEKVLNTERTLKTQAVNKLAEIMNRKDM | ||||||
Coiled coil | 1028-1115 | |||||
Sequence: KKGSTADLRKKEKENRKLQLELNQEKEKFNHMAIKYQKELSEMQAQLSEECTYRNELQMQLDSKESDIEQLREKLNDLQQRMDNSSVT | ||||||
Domain | 1128-1327 | PH | ||||
Sequence: ESRLEGWLSIPNRANIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPRIFQILYANEGECRKEAEMETVPQGDKTNCLPHKGHEFIPTLYHFPSNCEACAKPLWHVFKPPPALECRRCHVKCHKDHLDKKEDVIPPCKVNYDVTSARDMLLLALTQDEQKKWIGHLGKKIP | ||||||
Domain | 1238-1293 | Phorbol-ester/DAG-type | ||||
Sequence: GHEFIPTLYHFPSNCEACAKPLWHVFKPPPALECRRCHVKCHKDHLDKKEDVIPPC | ||||||
Region | 1321-1364 | Disordered | ||||
Sequence: HLGKKIPKTPPSTFSRASPRSMSTRSGPNQSFRKNPKSNTGKLS | ||||||
Compositional bias | 1331-1364 | Polar residues | ||||
Sequence: PSTFSRASPRSMSTRSGPNQSFRKNPKSNTGKLS |
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,364
- Mass (Da)158,462
- Last updated2019-02-13 v1
- Checksum663C897E2637FB85
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3P8RLE1 | A0A3P8RLE1_AMPPE | 1217 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1331-1364 | Polar residues | ||||
Sequence: PSTFSRASPRSMSTRSGPNQSFRKNPKSNTGKLS |
Keywords
- Technical term