A0A3P8NFU6 · A0A3P8NFU6_ASTCA

Function

Catalytic activity

  • (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
  • 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
  • N-(9Z-octadecenoyl)-ethanolamine phosphate + H2O = N-(9Z-octadecenoyl) ethanolamine + phosphate
    This reaction proceeds in the forward direction.
  • N-(octanoyl)-sphing-4-enine-1-phosphate + H2O = N-octanoylsphing-4-enine + phosphate
    This reaction proceeds in the forward direction.
  • a monoacyl-sn-glycero-3-phosphate + H2O = a monoacylglycerol + phosphate
    This reaction proceeds in the forward direction.
  • sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
    EC:3.1.3.4 (UniProtKB | ENZYME | Rhea)
  • a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.75 (UniProtKB | ENZYME | Rhea)
  • a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate
    This reaction proceeds in the forward direction.
    EC:3.1.3.106 (UniProtKB | ENZYME | Rhea)
  • an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
    This reaction proceeds in the forward direction.

Pathway

Lipid metabolism; phospholipid metabolism.
Phospholipid metabolism.

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcaveola
Molecular Functionlysophosphatidic acid phosphatase activity
Molecular Functionphosphatidate phosphatase activity
Biological Processphospholipid dephosphorylation
Biological Processphospholipid metabolic process
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipid phosphatase 1
  • EC number
  • Alternative names
    • Lipid phosphate phosphohydrolase 1
    • PAP2-alpha
    • Phosphatidate phosphohydrolase type 2a
    • Phosphatidic acid phosphatase 2a

Gene names

    • Name
      PLPP1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > African cichlids > Pseudocrenilabrinae > Haplochromini > Astatotilapia

Accessions

  • Primary accession
    A0A3P8NFU6

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Membrane raft
; Multi-pass membrane protein
Membrane, caveola
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-27Helical
Transmembrane59-79Helical
Transmembrane91-111Helical
Transmembrane166-186Helical
Transmembrane198-217Helical
Transmembrane229-251Helical

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Forms functional homodimers and homooligomers that are not required for substrate recognition and catalytic activity. Can also form heterooligomers with PLPP2 and PLPP3.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain102-244Phosphatidic acid phosphatase type 2/haloperoxidase
Region261-282Disordered
Compositional bias266-282Polar residues

Sequence similarities

Belongs to the PA-phosphatase related phosphoesterase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    282
  • Mass (Da)
    31,638
  • Last updated
    2019-02-13 v1
  • Checksum
    D53D0D931906F0B0
MFDMRGIPFVLLDIVCLVLGGLPLAAYNLGKIRPYQRGFFCTDDSIKYPFHSSTITSTVLYTVGFALPISCMIVGECLLVHLNRIKSKSSFGSYVACLYKAIGTFVFGAAMSQSLTDIAKYSIGRLRPHFLDLCRPDWKLINCSAGTYIEDFTCTGDAKQVNEARLSFYSGHSSFSMYCMLFLALYLQARLQADWARLLRPTIQFFLIAASVYTGLSRVSDYKHHWSDVLTGLIQGALMALLVVFFVSDFFKPQMESRKEADIPHTTLQETPTNGNHFESPN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias266-282Polar residues

Genome annotation databases

Similar Proteins

Disclaimer

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