A0A3P8NFU6 · A0A3P8NFU6_ASTCA
- ProteinPhospholipid phosphatase 1
- GenePLPP1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids282 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphateThis reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphateThis reaction proceeds in the forward direction.
- 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphateThis reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphateThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphateThis reaction proceeds in the forward direction.
- N-(9Z-octadecenoyl)-ethanolamine phosphate + H2O = N-(9Z-octadecenoyl) ethanolamine + phosphateThis reaction proceeds in the forward direction.
- N-(octanoyl)-sphing-4-enine-1-phosphate + H2O = N-octanoylsphing-4-enine + phosphateThis reaction proceeds in the forward direction.
- a monoacyl-sn-glycero-3-phosphate + H2O = a monoacylglycerol + phosphateThis reaction proceeds in the forward direction.
- sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphateThis reaction proceeds in the forward direction.
- an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphateThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; phospholipid metabolism.
Phospholipid metabolism.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | caveola | |
Molecular Function | lysophosphatidic acid phosphatase activity | |
Molecular Function | phosphatidate phosphatase activity | |
Biological Process | phospholipid dephosphorylation | |
Biological Process | phospholipid metabolic process | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhospholipid phosphatase 1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > African cichlids > Pseudocrenilabrinae > Haplochromini > Astatotilapia
Accessions
- Primary accessionA0A3P8NFU6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Membrane raft ; Multi-pass membrane protein
Membrane, caveola ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 7-27 | Helical | |||
Transmembrane | 59-79 | Helical | |||
Transmembrane | 91-111 | Helical | |||
Transmembrane | 166-186 | Helical | |||
Transmembrane | 198-217 | Helical | |||
Transmembrane | 229-251 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Forms functional homodimers and homooligomers that are not required for substrate recognition and catalytic activity. Can also form heterooligomers with PLPP2 and PLPP3.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 102-244 | Phosphatidic acid phosphatase type 2/haloperoxidase | |||
Region | 261-282 | Disordered | |||
Compositional bias | 266-282 | Polar residues | |||
Sequence similarities
Belongs to the PA-phosphatase related phosphoesterase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length282
- Mass (Da)31,638
- Last updated2019-02-13 v1
- ChecksumD53D0D931906F0B0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 266-282 | Polar residues | |||