A0A3P6HTM8 · A0A3P6HTM8_MESCO

Function

function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

FMN (UniProtKB | Rhea| CHEBI:58210 )

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.

Pathway

Amino-acid biosynthesis; beta-alanine biosynthesis.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functiondihydropyrimidine dehydrogenase (NADP+) activity
Molecular FunctionNADP binding
Molecular Functionuracil binding
Biological Processbeta-alanine biosynthetic process
Biological Processthymine catabolic process
Biological Processuracil catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydropyrimidine dehydrogenase [NADP(+)]
  • EC number
  • Short names
    DHPDHase
    ; DPD
  • Alternative names
    • Dihydrothymine dehydrogenase
    • Dihydrouracil dehydrogenase

Gene names

    • ORF names
      MCOS_LOCUS4629

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Cestoda > Eucestoda > Cyclophyllidea > Mesocestoididae > Mesocestoides

Accessions

  • Primary accession
    A0A3P6HTM8

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-301FAD/NAD(P)-binding
Domain349-653Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydropyrimidine dehydrogenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    662
  • Mass (Da)
    71,327
  • Last updated
    2019-02-13 v1
  • Checksum
    C2D2B157A491F885
MIGCGPASISCATYLARLGYRNVHIFERDSRVGGLSTSEIPQFRLPGSAVNFEVQLLLDLGVKIFTNRAFSASEANGITLSSLRKEGYKAIFLGFGLPNAHSTSVFSGLTPDQGYLTSKDFLPEVSSASKGCQGCPKARLPDFSGKRVVVLGAGDTAFDCATSALRCGAKRVTVSFRKSFTAINPVPEEMDLAWQEKCEFFPNLAPQRVKLGSDGKICEMEFIRREQNDDGSWYSDADQVIRIKTDYVITAYGSELNEPGVLKAMEGVELAPSGFSKGLPVVDLKSMRTNQEDVWCGGDLSGFAHTSVEATNDGKTAAWSIHSTLLGDEESHVTCLPRFTTPIDLVDVSVEMCGMRFENPFGLASAPPTTSSAMIRRAFEAGWGFAVTKTFGLDKELVTNVSPRIVRGPTGGHMYGPDQSGFCNIELISEKTAAYWIQSIKELKRDFPTKMVIASIMAKFDEQDWTQLTELTVKAKPDALELNLSCPHGMGERGMGLACGQDPALVRQICKWVKRAAGPNMPVFAKLTPNVSEIVEIAKAAREGGADGVTVINTVSGFMHLDSDSTPWPSVGKEKRTTYGGLSGNLIRPMALRAVSHIANKLPGFPILATGGIDSAEAGLQFLQAGASVLQVCSAIQNQDFTIIEDMVTGLKAGLYLDGREG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue662

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UXSR01001967
EMBL· GenBank· DDBJ
VDD78626.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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