A0A3P3YNY5 · A0A3P3YNY5_PLABS
- ProteinAdenylosuccinate lyase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids482 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate
Pathway
Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Molecular Function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity | |
Molecular Function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity | |
Biological Process | 'de novo' AMP biosynthetic process | |
Biological Process | 'de novo' IMP biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylosuccinate lyase
- EC number
- Short namesASL
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Sar > Rhizaria > Endomyxa > Phytomyxea > Plasmodiophorida > Plasmodiophoridae > Plasmodiophora
Accessions
- Primary accessionA0A3P3YNY5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Subunit
Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 373-457 | Adenylosuccinate lyase C-terminal | ||||
Sequence: LPFMATENILMACVQAGGDRQAVHEAIREHSMAAGCAVKQSGADNDLLERIANDPIFAPVASSLSTIVDPRAFIGRAPEQVDEFL |
Sequence similarities
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length482
- Mass (Da)53,830
- Last updated2019-02-13 v1
- ChecksumC8FD7A7752DDF663