A0A3P1WGV4 · A0A3P1WGV4_9ACTN
- ProteinPhosphoenolpyruvate-protein phosphotransferase
- GeneptsP
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids560 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
Catalytic activity
- L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate
Cofactor
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 189 | Tele-phosphohistidine intermediate | |||
Binding site | 289 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Binding site | 325 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Binding site | 414 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 437-438 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Binding site | 438 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 448 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Active site | 485 | Proton donor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | kinase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoenolpyruvate-protein phosphotransferase activity | |
Biological Process | phosphoenolpyruvate-dependent sugar phosphotransferase system | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoenolpyruvate-protein phosphotransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Propionibacteriales > Propionibacteriaceae > Tessaracoccus
Accessions
- Primary accessionA0A3P1WGV4
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 11-126 | Phosphotransferase system enzyme I N-terminal | |||
Domain | 153-224 | PEP-utilising enzyme mobile | |||
Domain | 251-520 | PEP-utilising enzyme C-terminal | |||
Sequence similarities
Belongs to the PEP-utilizing enzyme family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length560
- Mass (Da)57,869
- Last updated2019-02-13 v1
- MD5 Checksum7B4D61A87D7B149C59612DE92A61C195
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
RQYZ01000019 EMBL· GenBank· DDBJ | RRD45824.1 EMBL· GenBank· DDBJ | Genomic DNA |