A0A3P1SK99 · A0A3P1SK99_9GAMM

  • Protein
    UDP-2,3-diacylglucosamine hydrolase
  • Gene
    lpxH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 Mn2+ ions per subunit in a binuclear metal center.

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site8Mn2+ 1 (UniProtKB | ChEBI)
Binding site10Mn2+ 1 (UniProtKB | ChEBI)
Binding site41Mn2+ 1 (UniProtKB | ChEBI)
Binding site41Mn2+ 2 (UniProtKB | ChEBI)
Binding site79Mn2+ 2 (UniProtKB | ChEBI)
Binding site79-80substrate
Binding site114Mn2+ 2 (UniProtKB | ChEBI)
Binding site122substrate
Binding site160substrate
Binding site164substrate
Binding site167substrate
Binding site195Mn2+ 2 (UniProtKB | ChEBI)
Binding site195substrate
Binding site197Mn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextrinsic component of plasma membrane
Cellular Componentgas vesicle
Cellular Componentvesicle
Molecular Functionmanganese ion binding
Molecular FunctionUDP-2,3-diacylglucosamine hydrolase activity
Biological Processgas vesicle organization
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-2,3-diacylglucosamine hydrolase
  • EC number
  • Alternative names
    • UDP-2,3-diacylglucosamine diphosphatase

Gene names

    • Name
      lpxH
    • ORF names
      EHS89_20515

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JAMM 1525
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Oceanospirillaceae > Amphritea

Accessions

  • Primary accession
    A0A3P1SK99

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein
Gas vesicle

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-199Calcineurin-like phosphoesterase

Sequence similarities

Belongs to the LpxH family.
Belongs to the gas vesicle GvpC family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    237
  • Mass (Da)
    26,418
  • Last updated
    2019-02-13 v1
  • Checksum
    A54B1ADA9421DF4F
MRTLFISDLHLHQGRPDLTQALLHFLSNQAAGADQLYILGDLFEAWIGDDAIPPDQQPVISALKQLSSAGTKLFFQHGNRDFLIGPAFSELTGINILNETEIVDLPSSKALLMHGDQLCSDDTEYQALRHQLRNPQWQQAFLSKTISERLAVAQQLRSASKEKNAEKSMAIMDVNPTAVSEAMTDAGINLLIHGHTHRPAVHQIKTGRRIVLGDWDKTGWYLECTETGEQLIEFPLV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RQXV01000018
EMBL· GenBank· DDBJ
RRC96742.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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