A0A3N4HER3 · A0A3N4HER3_ASCIM

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site11-17GTP (UniProtKB | ChEBI)
Active site12Proton acceptor
Binding site12Mg2+ (UniProtKB | ChEBI)
Binding site12-15IMP (UniProtKB | ChEBI)
Binding site37-40IMP (UniProtKB | ChEBI)
Binding site39Mg2+ (UniProtKB | ChEBI)
Binding site39-41GTP (UniProtKB | ChEBI)
Active site40Proton donor
Binding site129IMP (UniProtKB | ChEBI)
Active site140
Binding site143IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site226IMP (UniProtKB | ChEBI)
Binding site241IMP (UniProtKB | ChEBI)
Binding site301-307substrate
Binding site305IMP (UniProtKB | ChEBI)
Binding site307GTP (UniProtKB | ChEBI)
Binding site333-335GTP (UniProtKB | ChEBI)
Binding site416-418GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • ORF names
      BJ508DRAFT_419643

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • RN42
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Pezizomycetes > Pezizales > Ascobolaceae > Ascobolus

Accessions

  • Primary accession
    A0A3N4HER3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    439
  • Mass (Da)
    48,095
  • Last updated
    2019-02-13 v1
  • Checksum
    0653FC09A4FE32C0
MTTIILGAQFGDEGKGKLVDVLCRSADICARSAGGSNAGHTVVANGITYDFHLLPSGLVHEQCTNVIGSGVVAHIPSFFDELEAAQSKGLNTEGRIKISNRAHIVLDLHRTVDGLEEEELGKNKSIGTTKRGIGPTYANKASRNGLRIADLYTWDTFEEKFRRLVAGYRKRFGHLEGFSYDDAAVEAELVRYKEYAERLKPFVVDAVTYMSKATASNKRIIVEGANALLLDIDYGTYPFVTSSNASLGGCITGLALNPLAIKEIIGVVKAYTTRVGGGPFPTELFDEVGEQIATIGHEIGVTTKRKRRCGWLDLVLVKYSHSVNHYTSINLTKLDILDAFDEIKVCEAYEVDGQIIEDFPADAETLAKVKPVYKSYPGWKSSPIMNTTSIKQWSQTTVDYVRHIEEFLGVKISSVGVGPKREHLIEAEVAGQSVLDNKN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ML119880
EMBL· GenBank· DDBJ
RPA72087.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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