A0A3M9M9Y7 · A0A3M9M9Y7_9BACT

  • Protein
    Bifunctional protein FolD
  • Gene
    folD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site164-166NADP+ (UniProtKB | ChEBI)
Binding site234NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • ORF names
      EFB08_19920

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • R-22-1c-1
  • Taxonomic lineage
    Bacteria > Bacteroidota > Cytophagia > Cytophagales > Hymenobacteraceae > Rufibacter

Accessions

  • Primary accession
    A0A3M9M9Y7

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-119Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain122-290Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    293
  • Mass (Da)
    31,724
  • Last updated
    2019-02-13 v1
  • Checksum
    A48ECE72C42B195F
MTLLDGKKTSEAIQQEIAAEVAEIKAQGGKVPHLAAILVGQDGGSMTYVNNKVIACERVGFASTLLHYETDITEEELLTKIKEINEDAEIDGLIVQLPLPKHISPDKVLEVMDYKKDVDGFHPVNVGRMVAGLPAYLPATPYGIMQLLERYNIDTKGKHCVVVGRSNIVGTPISILMSKCTIPGEATVTICHRNTVDLASHTRQADILIVAVGKPGLITEDMVKEGAVVIDVGTTRVNDATRERGWRLRGDVDFDNVAPKCSYITPVPGGVGPLTISMLLKNTLRAAKKEVYS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RJJD01000021
EMBL· GenBank· DDBJ
RNI22381.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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