A0A3M7QMR4 · A0A3M7QMR4_BRAPC

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site167ATP (UniProtKB | ChEBI)
Binding site251ATP (UniProtKB | ChEBI)
Binding site286ATP (UniProtKB | ChEBI)
Active site343
Binding site590Mn2+ (UniProtKB | ChEBI)
Binding site662substrate
Binding site759Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site789Mn2+ (UniProtKB | ChEBI)
Binding site791Mn2+ (UniProtKB | ChEBI)
Binding site926substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • ORF names
      BpHYR1_009057

Organism names

Accessions

  • Primary accession
    A0A3M7QMR4

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue759N6-carboxylysine
Modified residue1161N6-biotinyllysine

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain51-501Biotin carboxylation
Domain171-368ATP-grasp
Domain581-850Pyruvate carboxyltransferase
Domain1126-1195Lipoyl-binding

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,196
  • Mass (Da)
    132,829
  • Last updated
    2019-02-13 v1
  • Checksum
    342AB54A0C810733
MYSIQRKCPQALRFVHKKSSKRLKDHFLDSFNRDAIQQSFYSSNSGKVIKPIKKLMVANRGEIAIRVFRACTELDIRTVAIYSEQDDGQVHRIKADESYLIGKGLPPVQAYLSIPEIIKIAKDNDVEAIHPGYGLLSESGEFAKACFENGIRFVGPSPDVMFRMGNKTEARKAAIEAGLKVIPGTANPISEVADAKKFAQEHGLPIIFKAAHGGGGRGMRVVRSMEELEENFQRATSEAKSAFGNGDVFIERFLEKPRHIEVQIMGDKYNNVVHLYERDCSVQRRHQKVIEIAPAPSLPVEIRDRITSDAVRLAQHVGYQNAGTVEFLLDSSGQNFFIEVNARLQVEHTVTEEITGVDLVQTQIRVAEGHSLKDLNLEQKDIKVHGSALQCRMTTEDPAKNFQPDNGRIEVYRSGEGMGIRIDSANAFTGAVITPYYDSLLVKIIAHAKDHPSACSKMIRALKEFRIRGIKTNIPYLLNVLQNKQFLEGSVDTSFIDQNPDLFNFKPSQNRAQKLLNYLADVVVNGPLTELGTNLKPAEIVPTVPEVTNKVTTGWRDVYLRDGAKAFAKAIRDHTNSTNQLMLMDTTFRDAHQSLLATRVRTFDMKQIAPFVSNHFANLYSLECWGGATFDVSLRFLHECPWERLRELRKLIPNVPFQMLLRGANAVGYTNYPDNVVNEFCKLAVQNGMDVFRVFDSLNYVPNLVVGMDAVNNAGGIVEAAISYTGDVSDPTRTKYNLDYYVDVADQLVKAGAHVLSVKDMAGLLKPKATHMLIDAIRQRHPDVPIHLHTHDTAGTGVANYMAAAQAGCDIVDVAVDSMSGMTSQPSMGAVVASLQNTDRHTHIDLNSVFKYSSYWEQARLLYAPFECTTTMKSGNADVYMNEIPGGQYTNLQFQAFSLGLGTQFEEIKRAYTEANQLLGDIIKVTPSSKIVGDLAQFMVQNKLSSEDLVNKAEDLSFPTSVVEYMQGLIGQPPGGFPEPLRSKILKGKKRYDARPGSDLAPLDFEQVKKDLIEKYGEIVTDCDVMSHVMFPKVLEEFLDFKLKYGPVDKLNTRVFFVGPKIAEDLDIPIEKGKTLRVKLLAVGDLKNGEREVFFELNGQLRSLLVKDKSVQKDLKAQPKAVKGRKGSIGAPMPGTVIDVKCKEGDMVNKGDTLVVLSAMKMETVVKSPVSGKIVKLAVQNGQKLEGDDLLVEIDV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
REGN01005653
EMBL· GenBank· DDBJ
RNA12573.1
EMBL· GenBank· DDBJ
Genomic DNA

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Disclaimer

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