A0A3M0MS13 · A0A3M0MS13_9LACO

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Cellular Componentplasma membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      F5ESL0233_07260

Organism names

  • Taxonomic identifier
  • Strain
    • ESL0233
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus

Accessions

  • Primary accession
    A0A3M0MS13

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-31Helical
Transmembrane51-71Helical
Transmembrane83-101Helical
Transmembrane107-126Helical
Transmembrane138-157Helical
Transmembrane169-186Helical
Transmembrane223-247Helical
Transmembrane259-279Helical
Transmembrane288-306Helical
Transmembrane312-332Helical
Transmembrane344-369Helical
Transmembrane375-396Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-401Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    406
  • Mass (Da)
    43,776
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    12225D1E03FC6CD3F00988326C38E335
MMDERQMPKLLNYRWVILTIVALLDLTSNYIQFQISALAIQIMPMLHISTAQFQSLVMAPMLIAVFLSIPAGTLADKFGAKKIVSIGLIISVIGAFGRLIAHNFMTMMLMLLLFGVYMALLNANTLKIFGMWFKQDTNIAMGIFFASASVGIILSRITSPRFPSVQSAYMFSSILLLVLAICWLFFMKDMPAGEKLPPEAVKQDHTESSMEFFKAAARSKKTWIVAISVGVGMGASEAFSSIMPPAFAARGLSSVQGNTIAAIATIGSLCGSLFGPAIIGKARKAKPLMILVTLLAGMLIAITWFIPLGLPIIISLVLGGLFGAMTGPLMQAMPITFPEIGPKYAGSAGGLIGTVSLLFSYCIPVIISLVAGRNYMLTFIIQGIVLMLTAIFIAILPDANDARRRK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
REHH01000009
EMBL· GenBank· DDBJ
RMC40215.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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