A0A3M0LV23 · A0A3M0LV23_9LACO

  • Protein
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • Gene
    gpsA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site8-13NAD+ (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site12NADPH (UniProtKB | ChEBI)
Binding site49NADPH (UniProtKB | ChEBI)
Binding site109NADPH (UniProtKB | ChEBI)
Binding site109sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site109substrate
Binding site140sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site142sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site144NAD+ (UniProtKB | ChEBI)
Binding site144NADPH (UniProtKB | ChEBI)
Active site195Proton acceptor
Binding site195sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site249sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site259sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site260NAD+ (UniProtKB | ChEBI)
Binding site260NADPH (UniProtKB | ChEBI)
Binding site260sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site260-261substrate
Binding site261sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site284NADPH (UniProtKB | ChEBI)
Binding site286NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      F5ESL0246_02670

Organism names

  • Taxonomic identifier
  • Strain
    • ESL0246
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus

Accessions

  • Primary accession
    A0A3M0LV23

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-164Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain184-323Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    339
  • Mass (Da)
    36,724
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    B0E85769EBB942150E707CEED65EE26B
MAKIAVLGAGSWGTVLGSLLADNGNEVILYGNNVQVNQEINDNHTNEHYMKNWYVNETVRATDDLELALNEADIILFVLPTQAIREVAKKVNQVLTASKSKPLLVTATKGIEPGSKKLISEILTEEIYPNDTDKIVAISGPSHAESVAQKDLTAITCASDNADNAQKVQEIFTNGYLRLYTNTDLIGVEVAGAVKNVIAIAAGILVGKNYGDNAKAALMTRGLAEITRLGVNYFGAKPMTFSGLAGIGDLIVTCTSVNSRNWRCGKQIGEGKSLDYVLKNMGQVVEGATTVKAVHELCQEKQIDMPISEAIYRVLYQKANVDNEITKMMGRIPKPEIRL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
REHC01000006
EMBL· GenBank· DDBJ
RMC29146.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help