A0A3M0LPW0 · A0A3M0LPW0_9LACO

  • Protein
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
  • Gene
    murF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site109-115ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionUDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Molecular FunctionUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
Biological Processcell division
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
  • EC number
  • Alternative names
    • D-alanyl-D-alanine-adding enzyme

Gene names

    • Name
      murF
    • ORF names
      F5ESL0246_06610

Organism names

  • Taxonomic identifier
  • Strain
    • ESL0246
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus

Accessions

  • Primary accession
    A0A3M0LPW0

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-84Mur ligase N-terminal catalytic
Domain107-290Mur ligase central
Domain314-443Mur ligase C-terminal

Sequence similarities

Belongs to the MurCDEF family. MurF subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    455
  • Mass (Da)
    50,366
  • Last updated
    2019-02-13 v1
  • Checksum
    9E14A0353B8C8187
MKMQLAEIAKAINSTCEGDDQTIITSVAFDSRKIVLGGLFVPLQGERDGHDFINSAINNGASATLWEKGHPDKPTSIAVLEVEDPLDSMQKLAQYYLNKVNPTVVGITGSNGKTTTKDMTAAVLAKRFNVHKTAANFNNEIGVPMTILEMKPNTEILVLEMGMDHSGQLHHLSELTHPDVTVITMIGEAHIEFLGSRAAIADAKMEITDFLREDGELIYNGDEPLLCDRAQKIHQSMVTFGFAKTDSVYATEFRSYKHHASFMINDSDCKFTIPMIGKHNVSNALSALCVGKHFGEKDEEIAAALASFTPTANRMEWEKGDVGEDIMSDVYNSNPTAVRAVLASFGQIQITPGSRRIAVLGDMLELGERSADLHAQLVDCLDPQVINEVYLFGSEMKYLADALKDRYGLEYLHYYPQDQMQHMIADLKNDIKPHDIVVLKGSHGMHLEKVVERLR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
REHC01000011
EMBL· GenBank· DDBJ
RMC27609.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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