A0A3L8SU49 · A0A3L8SU49_CHLGU

Function

function

Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.
In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Cellular Componentside of membrane

Names & Taxonomy

Protein names

  • Recommended name
    Circumsporozoite protein

Gene names

    • ORF names
      DV515_00003206

Organism names

  • Taxonomic identifier
  • Strain
    • Red01
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Passeridae > Chloebia

Accessions

  • Primary accession
    A0A3L8SU49

Proteomes

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor
Cytoplasm

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane506-528Helical

Keywords

PTM/Processing

Keywords

Expression

Keywords

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region745-888Disordered
Compositional bias759-776Polar residues
Compositional bias777-793Basic and acidic residues

Sequence similarities

Belongs to the plasmodium circumsporozoite protein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    944
  • Mass (Da)
    105,697
  • Last updated
    2019-02-13 v1
  • Checksum
    1F9CEFA576D19D4A
MGARAGEGSALGGHLQRGRGLRVLVGVLGKRAGTLELKKDMRSKRTQDLSGQNETYVERFFKSIVSSALVDGLLHSSPLLSCPSSPHTEFLISAILNKKEFKKVKTVVKEFLGEVEYLLLEHPDHVAFSNDTVSVEYQYYSGGNVTAEHVSLLLLDASTSEIIARKQLPANQSQGTVVFECFHFKSAGDFLFRMVSPSDNTSAAQWSRSSMSTLHVEWPVFHIDLNRSLEVLRSSLQVGLFTNEQLCGMNNTVISLDVIFTSTLYEFRRVCSDETLGIRTSKGIPLSKSQWVEFDCPPVGQEVYITVLLKSLETRSIIASMGPVDLLHKFGYRLVVAAEDICKTLVQVFVISPPCTSMSGKIVVYKEAVKHLSQRTTWLYENILHPGDNRTEFNCTLFDVGKNKYCFDLLNFSNRSYFPARVKECILIQRNMETWSQWQPWSPCSVTCGDGIRERFRECLTSSPAKPGCAGSPRETSLCSLEECVSVQPPTPPSVQPGEDQKANNIVTITGISLCLFIIFATVLITLWRKLCRAQKCSTAVRRNSVHSPGFRKNSDEENICQGNKQRDSFVEGGDAPVNIPLTYRRSLQFAQEDDASGNENFQPNAQKIIPPIFSYRLAQQQLKEMKKKGLTETTKVYHVSQNPLTDTVLGATTMLPLSGENQEEAAANKFRIKSPFLDQPASQPKFLGEGSHPRLDFPFSQANPAISPTQTLVRRGHFKHQDNRVDMPERGCHKNSQFRRTASFHETKKARPFRERSMSTLTPRQTPLYNSRTRTWDQGLEDRTRPKSRNANPACEKLDQPHSAVLGSEPQGHGAKHPHHRAGPPVRKLDLITDRQPAGQEKAAEKPEPSRSKRGPSPNPRGVWRKETGPNGKDNSQRGLSISPAQYRRDKCQSFPLDPEFAFYDNSTFGLTEAEQQMIDLPGYFGSNEEDETSTLSIEKLVI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias759-776Polar residues
Compositional bias777-793Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QUSF01000006
EMBL· GenBank· DDBJ
RLW08368.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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