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A0A3L8SS39 · A0A3L8SS39_CHLGU

Function

function

Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentchloride channel complex
Cellular Componentcytosol
Cellular Componentearly endosome membrane
Cellular Componentendoplasmic reticulum membrane
Cellular Componentrecycling endosome membrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionbicarbonate transmembrane transporter activity
Molecular Functionintracellularly ATP-gated chloride channel activity
Molecular Functionisomerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cystic fibrosis transmembrane conductance regulator
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family C member 7
    • Channel conductance-controlling ATPase
    • cAMP-dependent chloride channel

Gene names

    • ORF names
      DV515_00004404

Organism names

  • Taxonomic identifier
  • Strain
    • Red01
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Passeridae > Chloebia

Accessions

  • Primary accession
    A0A3L8SS39

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein
Early endosome membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Recycling endosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane305-330Helical
Transmembrane360-379Helical
Transmembrane433-455Helical
Transmembrane461-480Helical
Transmembrane550-568Helical
Transmembrane574-594Helical

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain310-602ABC transmembrane type-1
Domain655-888ABC transporter
Region896-927Disordered
Compositional bias910-927Basic and acidic residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    927
  • Mass (Da)
    104,550
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    FEF9B0589221C23E899E67262F03C035
LFRAVYKDADLYLLDSPFGHLDIFTEKEIFESCMCKLMANKTRILVTSKLEHLKIADKILILHEGSCYFYGTFSELQGQRPDFSSELMGFDSFDQFSAERRNSILTETLRRFSIEGEGMGSRNEIKKQSFKQKSDFNDKRKSSVIINPLNANRKFSIVQKNGLQVNGLEDGHGDPPERRLSLVPDVEQGDVALLRAGMLKADHLLQGRRRQSVLNLMTSAPVNYGPNFSKKGSTTFRKMSMVPQTNLSSEIDIYTRRVSRDSVLDITDEINEEDLKECFSDDAESMGTVTTWNTYFRYVTIHKNLIFVLILCVTVFLVEVAASLGGVWFLQKTALKANSTQSENSTSDKPPVIVTDTSSYYIVYIYVGVADTLLAMGIFRGLPLVHTLITVSKTLHQKMVHAVLHAPMSTFNSWKAGGMLNRFSKDTAVLDDLLPLTVFDFIQLILIVIGAITVVSILEPYIFLASVPVIGAFILLRAYFLHTSQQLKQLESEARSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEIIFVVFFVAVVFISIITTGEGPGTAGIILTLAMNIMGTLQWAVNSSIDVDSLMRSVGRIFKLIDMPTEETKSIKPQKNNQFSDALVIENMHVKEEKNWPSGGQMSVKDLTAKYGDGGAAVLENISFSISSGQRVGLLGRTGSGKSTLLFAFLRLLNTEGDIQIDGVSWNTVSVQQWRKAFGVIPQKVFIFSGSFRMNLDPYGQWNDEEIWKVAEEVGLKSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTSQVIRKTLKHAFANCTVILSEHRLEAMLECQRFLVIEDNRLRQYESIQKLLNEKSSFRQAISHAERLKLLPAHHRNSSKRKPRPQITALQEETEEEVQETRL

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias910-927Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QUSF01000009
EMBL· GenBank· DDBJ
RLW06538.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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