A0A3L8SS39 · A0A3L8SS39_CHLGU
- ProteinCystic fibrosis transmembrane conductance regulator
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids927 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+This reaction proceeds in the forward direction.
- chloride(in) = chloride(out)
- hydrogencarbonate(in) = hydrogencarbonate(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | chloride channel complex | |
Cellular Component | cytosol | |
Cellular Component | early endosome membrane | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | recycling endosome membrane | |
Molecular Function | ABC-type transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | bicarbonate transmembrane transporter activity | |
Molecular Function | intracellularly ATP-gated chloride channel activity | |
Molecular Function | isomerase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCystic fibrosis transmembrane conductance regulator
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Passeridae > Chloebia
Accessions
- Primary accessionA0A3L8SS39
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Early endosome membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Recycling endosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 305-330 | Helical | |||
Transmembrane | 360-379 | Helical | |||
Transmembrane | 433-455 | Helical | |||
Transmembrane | 461-480 | Helical | |||
Transmembrane | 550-568 | Helical | |||
Transmembrane | 574-594 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 310-602 | ABC transmembrane type-1 | |||
Domain | 655-888 | ABC transporter | |||
Region | 896-927 | Disordered | |||
Compositional bias | 910-927 | Basic and acidic residues | |||
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length927
- Mass (Da)104,550
- Last updated2019-02-13 v1
- MD5 ChecksumFEF9B0589221C23E899E67262F03C035
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Compositional bias | 910-927 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QUSF01000009 EMBL· GenBank· DDBJ | RLW06538.1 EMBL· GenBank· DDBJ | Genomic DNA |