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A0A3L8SFZ0 · A0A3L8SFZ0_CHLGU

Function

function

Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • 2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.56 (UniProtKB | ENZYME | Rhea)
  • 8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • N6-methyl-ATP + H2O = N6-methyl-AMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • N6-methyl-dATP + H2O = N6-methyl-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+
    This reaction proceeds in the forward direction.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
Molecular Functionmetal ion binding
Biological ProcessDNA protection

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxidized purine nucleoside triphosphate hydrolase
  • EC number
  • Alternative names
    • 2-hydroxy-dATP diphosphatase
    • 7,8-dihydro-8-oxoguanine triphosphatase
    • 8-oxo-dGTPase
    • Methylated purine nucleoside triphosphate hydrolase
    • Nucleoside diphosphate-linked moiety X motif 1

Gene names

    • ORF names
      DV515_00007856

Organism names

  • Taxonomic identifier
  • Strain
    • Red01
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Passeridae > Chloebia

Accessions

  • Primary accession
    A0A3L8SFZ0

Proteomes

Subcellular Location

Cytoplasm
Nucleus

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-132Nudix hydrolase

Sequence similarities

Belongs to the Nudix hydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    156
  • Mass (Da)
    18,154
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    6D6DAF247297E80A3470C71813F447CD
MHTSRLFTLVLVVQPSRVLLGMKKRGFGAGLWNGFGGKVQPGESIEEAARRELLEESGLTVDTLQKMGQITFEFVGNSELMDVHIFRADHFHGEPTESDEMRPQWFQLDEVPFHHMWPDDSYWFPLVLQRKLFRGYFKFQGQDTILEHSLKEVEEV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QUSF01000022
EMBL· GenBank· DDBJ
RLW01413.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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