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A0A3L8SFJ5 · A0A3L8SFJ5_CHLGU

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell projection
Cellular Componentcentrosome
Cellular Componentcytosol
Cellular Componentmicrotubule
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Cellular Componentspindle
Molecular Functioncysteine-type deubiquitinase activity
Molecular FunctionK63-linked deubiquitinase activity
Biological Processinnate immune response
Biological Processnecroptotic process
Biological Processnegative regulation of NF-kappaB transcription factor activity
Biological Processpositive regulation of extrinsic apoptotic signaling pathway
Biological Processprotein K63-linked deubiquitination
Biological Processregulation of intrinsic apoptotic signaling pathway
Biological Processregulation of mitotic cell cycle
Biological ProcessWnt signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin carboxyl-terminal hydrolase CYLD
  • EC number
  • Alternative names
    • Deubiquitinating enzyme CYLD
    • Ubiquitin thioesterase CYLD
    • Ubiquitin-specific-processing protease CYLD

Gene names

    • ORF names
      DV515_00008257

Organism names

  • Taxonomic identifier
  • Strain
    • Red01
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Passeridae > Chloebia

Accessions

  • Primary accession
    A0A3L8SFJ5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Interacts (via CAP-Gly domain) with IKBKG/NEMO (via proline-rich C-terminal region). Interacts with TRAF2 and TRIP. Interacts with PLK1, DVL1, DVL3, MAVS, TBK1, IKKE and RIGI. Interacts (via CAP-Gly domain) with microtubules. Interacts with HDAC6 and BCL3. Interacts with MAP3K7. Identified in a complex with TRAF6 and SQSTM1. Interacts with OPTN and SQSTM1. Interacts with CEP350. Interacts with RNF31; the interaction is indirect and is mediated via SPATA2. Interacts with SPATA2 (via the PUB domain); the interaction is direct and recruits CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain161-199CAP-Gly
Region309-348Disordered
Compositional bias334-348Polar residues
Region379-407Disordered
Compositional bias383-407Polar residues
Domain489-532CAP-Gly
Domain589-947USP

Sequence similarities

Belongs to the peptidase C19 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    953
  • Mass (Da)
    106,976
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    3341802FB1C506658A2C24E8DD795983
MNSGLWSQEKASSSYWEERIFYLLLQECSVIDKQTQKLLKVPKGSIGQFFQDRSSVAHSRNIPCKGKKLQIGLKILEQPHAILFVDEKDVIEINEKLAELLLAITNCEERYSLFKSKSRLAKGVQIDIGSPVRVQLRSGDEKYPGVVRFRGPLMQERSLTGIYFGVELLEEGRGQGFTDGQYQGKQLFRCDEDCGVFVALDKLELVEDDDNELESDYAAPVDTMQVELPPLEINSRVSLKIGESIEYGTVIFCDVLPGNESLGYVVGVDMDNPIGNWDGRYNGIQLCSFASVESTLLLHINDVIPETVSQDRRPPKLAYTSRSGDKGLFNHSKPKAIGSTSEPGSRSRSEVFYTLNGSSVDSQPQTKTKSPWYIDEAAEDPSKSLTDSSPGFGHSSPPLQPPLTNSVSQENRFHSLPFSLTKTTSTNGTIGHSPLSLSVQSVMGDVTTTATQESPSAASPIGNSHGLEAGSLAEVKENPPFYGVIRWIGQPPGVNEVLAGLELEDECAGCTDGTFKGTRYFTCAPKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLETMIGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKEMNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLKIRSAGQKVQDCYFYQIFMDKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELNITDLLEDTPRQCRICRGLAMYECRECYEDTDISAGKIKQFCKTCNTQVHLHPKRQSHKFNPLSLPKDLPDWDWRHGCIPSQKMELFAVLCIETSHYVAFVKYGRDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEELHSLDSRKIQGCARRLLCDAYMCMYQSPTMSLYK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias334-348Polar residues
Compositional bias383-407Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QUSF01000023
EMBL· GenBank· DDBJ
RLW01265.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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