A0A3L7B262 · A0A3L7B262_9ACTN
- ProteinAminomethyltransferase
- GenegcvT
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids376 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The glycine cleavage system catalyzes the degradation of glycine.
Catalytic activity
- (6S)-5,6,7,8-tetrahydrofolate + N6-[(R)-S8-aminomethyldihydrolipoyl]-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 207 | substrate | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | glycine cleavage complex | |
Molecular Function | aminomethyltransferase activity | |
Molecular Function | methyltransferase activity | |
Molecular Function | transaminase activity | |
Biological Process | glycine decarboxylation via glycine cleavage system | |
Biological Process | methylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAminomethyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micromonosporales > Micromonosporaceae > Micromonospora
Accessions
- Primary accessionA0A3L7B262
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
The glycine cleavage system is composed of four proteins: P, T, L and H.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 18-269 | Aminomethyltransferase folate-binding | ||||
Sequence: LHERHTAAGAKFAPFGGWEMPLEYAGGGVLKEHTAVRGAVGVFDVSHLGKARVSGPGAADFVNACLSNDLGRIGPGRAQYTLCCDDATGGVVDDIIAYLYAEDHVFLIPNAANTAEVVRRLRAAAPEQVTVSDEHEAYAVLAVQGPRSAELLGALGLPTEHGYMSFSAATLAGVELTVCRTGYTGELGYELVVPAEQAVTVWDALFAAGESFGLRACGLAARDTLRTEMGYPLHGQDLSLDITPVQARSGWA | ||||||
Domain | 293-370 | Glycine cleavage T-protein C-terminal barrel | ||||
Sequence: RTLRGLVAVDRAIPRPGMTLYVGDVQVGTVTSGTFSPTRKQGIALALLDTDAKLADGDEVEIDIRGRRAPMQITKPPF |
Sequence similarities
Belongs to the GcvT family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length376
- Mass (Da)39,854
- Last updated2019-02-13 v1
- Checksum2AB1C945E84852EB