A0A3L6QEW9 · A0A3L6QEW9_PANMI
- ProteinDNA topoisomerase 2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1472 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Catalytic activity
Cofactor
Protein has several cofactor binding sites:
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA topological change |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 2
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > PACMAD clade > Panicoideae > Panicodae > Paniceae > Panicinae > Panicum
Accessions
- Primary accessionA0A3L6QEW9
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for region, domain, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-21 | Disordered | ||||
Sequence: MMGPLHSSSGHNAAAGGGGGK | ||||||
Domain | 447-561 | Toprim | ||||
Sequence: CTLILTEGDSAKALAMSGIAEVGRDHYGVFPLRGKLLNVREANHKQIMDNAEIQNIKQILGLQHGKLYDSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLV | ||||||
Coiled coil | 1016-1043 | |||||
Sequence: DKRKKTLLQNIKLDLKKLENKVRFIRCV | ||||||
Region | 1078-1102 | Disordered | ||||
Sequence: EPVAVGATEEEENEESPEAANGVDP | ||||||
Compositional bias | 1169-1191 | Basic and acidic residues | ||||
Sequence: EEERRMKREKNANKEGGKAGPKK | ||||||
Region | 1169-1472 | Disordered | ||||
Sequence: EEERRMKREKNANKEGGKAGPKKQRKKAEVKLPKVESDTEGDGAEPVVAKRGAQQKKPAKKVNGAGSDDEDYVAENAKPEQQKKKQTKKASAPVDEDEDDMPTLKARIAAFTLNDSSPDSSAMETETTEEQNGDKGVKGPSRRGGGKKVSSSLAVISDDEDDDVDFAMEVPEVQAQKKGRGRKTAAATQPKAAATRKRAPAKGKAMMLKTTDDSNTSAPSPEKEVRKSGSILQRGSTASSSEITAEASPPSGSSAEPAAAPQPRRTARATTSKPVYISESDPEDEVVEVTDDSDFDVDGDSDDE | ||||||
Compositional bias | 1197-1213 | Basic and acidic residues | ||||
Sequence: EVKLPKVESDTEGDGAE | ||||||
Compositional bias | 1230-1272 | Basic and acidic residues | ||||
Sequence: VNGAGSDDEDYVAENAKPEQQKKKQTKKASAPVDEDEDDMPTL | ||||||
Compositional bias | 1281-1295 | Polar residues | ||||
Sequence: LNDSSPDSSAMETET | ||||||
Compositional bias | 1377-1391 | Polar residues | ||||
Sequence: KTTDDSNTSAPSPEK | ||||||
Compositional bias | 1398-1419 | Polar residues | ||||
Sequence: SILQRGSTASSSEITAEASPPS | ||||||
Compositional bias | 1449-1472 | Acidic residues | ||||
Sequence: DPEDEVVEVTDDSDFDVDGDSDDE |
Sequence similarities
Belongs to the type II topoisomerase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,472
- Mass (Da)164,966
- Last updated2019-02-13 v1
- Checksum63A6F2A054136821
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1169-1191 | Basic and acidic residues | ||||
Sequence: EEERRMKREKNANKEGGKAGPKK | ||||||
Compositional bias | 1197-1213 | Basic and acidic residues | ||||
Sequence: EVKLPKVESDTEGDGAE | ||||||
Compositional bias | 1230-1272 | Basic and acidic residues | ||||
Sequence: VNGAGSDDEDYVAENAKPEQQKKKQTKKASAPVDEDEDDMPTL | ||||||
Compositional bias | 1281-1295 | Polar residues | ||||
Sequence: LNDSSPDSSAMETET | ||||||
Compositional bias | 1377-1391 | Polar residues | ||||
Sequence: KTTDDSNTSAPSPEK | ||||||
Compositional bias | 1398-1419 | Polar residues | ||||
Sequence: SILQRGSTASSSEITAEASPPS | ||||||
Compositional bias | 1449-1472 | Acidic residues | ||||
Sequence: DPEDEVVEVTDDSDFDVDGDSDDE |
Keywords
- Technical term