A0A3L6QEW9 · A0A3L6QEW9_PANMI

Function

function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Functionmetal ion binding
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 2
  • EC number

Gene names

    • ORF names
      C2845_PM12G24320

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > PACMAD clade > Panicoideae > Panicodae > Paniceae > Panicinae > Panicum

Accessions

  • Primary accession
    A0A3L6QEW9

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, coiled coil, compositional bias.

TypeIDPosition(s)Description
Region1-21Disordered
Domain447-561Toprim
Coiled coil1016-1043
Region1078-1102Disordered
Compositional bias1169-1191Basic and acidic residues
Region1169-1472Disordered
Compositional bias1197-1213Basic and acidic residues
Compositional bias1230-1272Basic and acidic residues
Compositional bias1281-1295Polar residues
Compositional bias1377-1391Polar residues
Compositional bias1398-1419Polar residues
Compositional bias1449-1472Acidic residues

Sequence similarities

Belongs to the type II topoisomerase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,472
  • Mass (Da)
    164,966
  • Last updated
    2019-02-13 v1
  • Checksum
    63A6F2A054136821
MMGPLHSSSGHNAAAGGGGGKTIEEMYQKKTQLEHILLRPDTYIGSVEKHTQTLWVYEGGAMVNRAVTYVPGLYKIFDEILVNAADNKQRDPRMDSLRVEIDVEGCCVSVYNNGDGIPVEVHQEEGVYVPEMIFGHLLTSSNYNDNEKKTTGGRNGYGAKLTNIFSTEFVIETADGHRQKKYKQVFSENMGKKSQPQITKCKQGENWTRVTFQPDLAKFNMTHLEDDVVALMRKRVIDMAGTLGKTVKVELDGQKLSVKSFSDYVDLYMKSANSDRPAPLQRVYEKVNDRWEVCVTLSEGQFQQVSFVNRIATIRGGTHVDYITNQIANYVMTIVNKKNKNANMKVHNVKSHLWVFVNALIDNPAFDSQTKETLTTRQGSFGSKCELSNNFLKNVEKIGVVSNVLSWADFKLSKELKKTDGSKKSRISGIPKLEDANEAGGKDSDKCTLILTEGDSAKALAMSGIAEVGRDHYGVFPLRGKLLNVREANHKQIMDNAEIQNIKQILGLQHGKLYDSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFTTPIIKATKNKTTKSFYTIPEYEDWKRNLGASASSWTIKYYKGLGTSTSKEGKEYFSDISNHKKDFVWVDDQDGNEIELAFSKKRIADRKQWLTNFQPGTYLDHREKKIKYRDFINKELILFSMADLQRSIPSMVDGFKPGQRKILFCAFKRNLVKETKVAQFSGYVSEHSAYHHGEQSLASTIVGMAQSFVGSNNINLFYPGGQFGTRAQGGKDAASARYIFTKLSHVTRSIFPKDDDILLNYLNEDGQSIEPSWYVPILPMVLVNGSEGIGTGWSTYIPNYNPRDIVANLRRLLNDKSTVPMHPWYRGFKGSIVKSHNAKVAGATYTFTGIIEAVDSTTLRITELPIRRWTQDYKEFIESVTLDPKNKDKETFIEDCTMQGDSDDVYFVLKLTEENMNKVMEEGLVKKFKLTTTIGTSNMHLFDSDGKIRKYDTPEQILEEFYKLRLEFYDKRKKTLLQNIKLDLKKLENKVRFIRCVVENEIVVNNRKRADLFLELREKNFDPFPMKKKKAEPVAVGATEEEENEESPEAANGVDPSDYEYLISMAIGTLTLEKIQDLNAEREKLVNEVEELENTTPKSLWLRDLDTFEKDLDVLDQMDLAEEEERRMKREKNANKEGGKAGPKKQRKKAEVKLPKVESDTEGDGAEPVVAKRGAQQKKPAKKVNGAGSDDEDYVAENAKPEQQKKKQTKKASAPVDEDEDDMPTLKARIAAFTLNDSSPDSSAMETETTEEQNGDKGVKGPSRRGGGKKVSSSLAVISDDEDDDVDFAMEVPEVQAQKKGRGRKTAAATQPKAAATRKRAPAKGKAMMLKTTDDSNTSAPSPEKEVRKSGSILQRGSTASSSEITAEASPPSGSSAEPAAAPQPRRTARATTSKPVYISESDPEDEVVEVTDDSDFDVDGDSDDE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1169-1191Basic and acidic residues
Compositional bias1197-1213Basic and acidic residues
Compositional bias1230-1272Basic and acidic residues
Compositional bias1281-1295Polar residues
Compositional bias1377-1391Polar residues
Compositional bias1398-1419Polar residues
Compositional bias1449-1472Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PQIB02000012
EMBL· GenBank· DDBJ
RLM78272.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp