A0A3G9E9U3 · A0A3G9E9U3_9ADEN

  • Protein
    Pre-hexon-linking protein VIII
  • Gene
    L4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Hexon-linking protein-C: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
Hexon-linking protein-N: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site.

122620406080100120140160180200220
TypeIDPosition(s)Description
Site111-112Cleavage; by viral protease
Site156-157Cleavage; by viral protease

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentviral capsid
Molecular Functionhexon binding

Names & Taxonomy

Protein names

  • Recommended name
    Pre-hexon-linking protein VIII
  • Alternative names
    • Pre-protein VIII
      (pVIII
      )
  • Cleaved into 2 chains
    • Hexon-linking protein-N
      Alternative names: 12.1 kDa protein VIII
      , Protein VIII-N
    • Hexon-linking protein-C
      Alternative names: 7.6 kDa protein VIII
      , Protein VIII-C

Gene names

    • Name
      L4

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Vs9
  • Taxonomic lineage
    Viruses > Varidnaviria > Bamfordvirae > Preplasmiviricota > Tectiliviricetes > Rowavirales > Adenoviridae > Mastadenovirus

Accessions

  • Primary accession
    A0A3G9E9U3

Proteomes

Subcellular Location

Hexon-linking protein-N

Virion
Note: Located on the inner side of the capsid shell. Present in 120 copies per virion.

Hexon-linking protein-C

Virion
Note: Located on the inner side of the capsid shell. Present in 120 copies per virion.

Pre-hexon-linking protein VIII

Host nucleus

Keywords

PTM/Processing

Features

Showing features for peptide, chain, modified residue.

TypeIDPosition(s)Description
PeptidePRO_50183424881-111Hexon-linking protein-N
ChainPRO_50233750371-226Pre-hexon-linking protein VIII
Modified residue64Phosphothreonine; by host
Modified residue120Phosphoserine; by host
PeptidePRO_5018342489157-226Hexon-linking protein-C

Post-translational modification

Cleaved by the viral protease during virion maturation. May cause the middle segment to be shed from the capsid.

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with the peripentonal hexons as well as the hexons in the facets. Part of a complex composed of the core-capsid bridging protein, the endosome lysis protein VI and the hexon-linking protein VIII; these interactions bridge the virus core to the capsid.

Family & Domains

Sequence similarities

Belongs to the adenoviridae hexon-linking protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    226
  • Mass (Da)
    24,635
  • Last updated
    2019-02-13 v1
  • Checksum
    5F651D4C1E772FBE
MAKEIPAPYMWSYQPQTGHAAGAAQDYSTQMNWLSAGPAMINQVFEIRDLRNKILMTQAKITETPRTIMDPPVWPAALVTQQEPPPSTVALPRNYALENAMTNAGVQLAGGRRLPVTPSSVDIKDWALRGRGIQLSEGFPSVSQLRADGTFQLGGGSRSSFDPTQAFLTIQQASTLPRSGGIGSVQFVREFVPEVYLNPFSGPANTFPDQFIPNYDIVTNSVDGYD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3G9F1D7A0A3G9F1D7_9ADENL4694

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC385827
EMBL· GenBank· DDBJ
BBE29319.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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