A0A3G6V9Y8 · A0A3G6V9Y8_9RHAB

Function

Catalytic activity

  • GTP + H2O = GDP + phosphate + H+
  • a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-homocysteine + H+
    EC:2.1.1.375 (UniProtKB | ENZYME | Rhea)
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine + H+
  • a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H+ = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate
    EC:2.7.7.88 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentvirion component
Molecular FunctionATP binding
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular FunctionRNA-dependent RNA polymerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA-directed RNA polymerase
  • EC number
  • Alternative names
    • Replicase
    • Transcriptase

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TP1
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Rhabdoviridae > Betarhabdovirinae > Cytorhabdovirus > Cytorhabdovirus oryzae

Accessions

  • Primary accession
    A0A3G6V9Y8

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain566-755RdRp catalytic

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,066
  • Mass (Da)
    235,884
  • Last updated
    2019-02-13 v1
  • Checksum
    F2B949A02D61B328
MDLDDGGLWRRARGLGDYHLRSALVTPSLERFRSRKGRHREQLCFDRMKSLGWMLRWVDQGKLLGYLMVEANKSLPKSIANQELLVETLKLEYGCLRQIIMTDGDLHDQVISYLDRKSISTHYTHGREVFQEALIVVMALSSGREPPDHVNNLGCEMLNEELEVPVVRTYGVIFYLFGDLIYVKYPEEEGMITLDMFRNLTDKFSERENIMIATQLGTEILQEIYPSETVLKTVFSLWDKGLLKEGNDFYTVVKTFEAIINGMLIKNNDGTYYDPSAYLRETIMGLPVRLRDYAQTLVSYLDSLPFNPHHLSQIGGLFRLWGHPIVDPNAGVRKVRLLGTADKMNLTHIPTLAERKFKEIFYLSYYEKHRVYPNHNLNGEIEGSYLLSQLAQMALVNPKHANYSLVDWDSVNTLETFPFPKSFNLSLIIADKAVSPNREEWLELRRKGGTQMDPHIRRGPLKAMKDGVIDCEKLLRKIDRNPSGLAKKHRIIGLYPKEREENMVPRMFALMSFDMRAFSVVSESMIADHIIPHIEGVTMTKSMLALQKEMIISTKSQASSTQSDSITFCLNIDFEKWNLNFRRWMTEGVFREMGRLFGLPEIFNRTYDIFKKSIIYLADGSFDLLLTDELEIEPGTNPDCAYTGHVGGFEGLRQKGWTVFTAVLISSICDEMGIKTHLMGQGDNQVLMLTIYSRAARETGDLKSAPAVLEITNTLETFKSRLVSLFANLGLPIKPLETWVSEELFAYGKTPIYRAVPLAMSLKRISRVFAFSNEDLMTLSNALGAISANAQAASMCDVHPMVSYAIAKWQHLCCAIIFSNYHPLCGCAPHVSGEEWAIKLRLPSGKKIQETSDEEIDERDLMKLIVTIPRSLGGYNTLTLYEMIMRGFSDPVSRDMCWLFAIASESTGKLRGYLINWIKPIVSPEVNAQHLIQDPTALNLLVPPNATSVIKRMIDKSLEALPKRSQFAVWFSEILEISGDKEISKLAEALTRTDSLNPRFLHDILGATLYGYCTAITSKVDKTVTLSRMALASKDVVGALIKGEMRLYSYFGWRTLQSRGLPLTTRCPNKWVRIIRDISWQKQIKAVSVPYPTHFLSEDISETDRPDSWIECYIDDAPTSDRSCLIYSTGKALPYLGSVTREKLTTRGAKAAYGTEPLVLRPINLVRTIGWFIEEDSNFAELIKMLLGAVTDLPIEEVLYIPEMVSGSMAHRYLDMSTQHGSLWMPLYGPATFLHMSTNTFVQYLKGTENVTLHFQCVMGLIQYAIVNKALGECPTKRMTRFFRSCPDCIVPIDDTLEDLPEVPSLDLIPERTTNPYLYLKKEKIELNVRHRLAVINEIRVIARDEIEETPLLANNTLEDVMSLRAAQRIFYTAKGKEAQWDLQTADREGYLKLDFVSVIRKIIGHLFVMESETLKAGSDYPTFQLQQRRIMRRVRQSDTSNFVHLGGFFCWQESIARIQKLKWSVMPATFPITAESVSLAAKMSLIGAMTSGLTPKRCDGVLAENLIPDVTRQAKNIICLDKVFQSRCDYCYTAAMTNRWSDSINSDSIFNMRCERGHTILSPRMLHQLRRTILPEGALYTLAVRVVHQSPPEASQPLQIIPCRRERYQILSEADMPRQTGYSGVYRRPTNQICMYTEVELAKKYRLPTNSLYRILDLHDCFFSQKLMDTRGNILVVGDGYGYSSLLTKCLNPDRNVVSWTYIEPSEALPHSLRISKPPMHYKADVQIDSSPSIDRISDIHNSSYPDEFAKVVTKNWITALISDIETVYVSGEKSVSSLINLAWNNQIQLGALKLELMTDPLEKVVEYAHNAYQRWELFTLPGANLGGGVLYIGFYGRREKLTGYIIPHSGVETLMDRLATEVDEDRGRLRAEDRDRWEQLDTMESKIHLQQYHKMRLDLWFGSAYLSGYLSEDMTEFFYSVKTSYRPPAISWEKGNQARYLYGSREEILFMSMITVALSSYLEDQDVLREFLSSSGWKLQWKKDKKNPRHWSPYLERSDSQLVWKKNKAMIFKLVSVLRGSKPREEYKMGKASDSIVFRYIPRKVREGEVPLCFPISKVASMSV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH720464
EMBL· GenBank· DDBJ
AZB50417.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp