A0A3G2K2Y9 · A0A3G2K2Y9_9CRUS

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Peracarida > Amphipoda > Senticaudata > Gammarida > Gammaridira > Gammaroidea > Gammaridae > Gammarus

Accessions

  • Primary accession
    A0A3G2K2Y9

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane42-67Helical
Transmembrane88-110Helical
Transmembrane130-155Helical
Transmembrane167-194Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    209
  • Mass (Da)
    22,201
  • Last updated
    2019-02-13 v1
  • Checksum
    BFC37E5982D18E3C
TLYFVLGAWASVVGTSLSVIIRSELSAPGNLIGDDQLYNVMVTAHAFVMIFFMVMPIMIGGFGNWLVPLMLGSPDMAFPRMNNMSFWLLPPSLTLLLMSGLVESGVGTGWTVYPPLAGATAHSGGAVDLAIFSLHLAGASSILGAINFISTVLNMRSPGMPMDQMPLFVWSVFITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPSGG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue209

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG311308
EMBL· GenBank· DDBJ
AYN51679.1
EMBL· GenBank· DDBJ
Genomic DNA
MG311657
EMBL· GenBank· DDBJ
AYN52028.1
EMBL· GenBank· DDBJ
Genomic DNA
MG312565
EMBL· GenBank· DDBJ
AYN52936.1
EMBL· GenBank· DDBJ
Genomic DNA
MG314527
EMBL· GenBank· DDBJ
AYO25787.1
EMBL· GenBank· DDBJ
Genomic DNA
MG315502
EMBL· GenBank· DDBJ
AYO26762.1
EMBL· GenBank· DDBJ
Genomic DNA
MG315574
EMBL· GenBank· DDBJ
AYO26834.1
EMBL· GenBank· DDBJ
Genomic DNA
MG317915
EMBL· GenBank· DDBJ
AYP37710.1
EMBL· GenBank· DDBJ
Genomic DNA
MG319326
EMBL· GenBank· DDBJ
AYP39121.1
EMBL· GenBank· DDBJ
Genomic DNA
MG319339
EMBL· GenBank· DDBJ
AYP39134.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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