A0A3G1T2I9 · A0A3G1T2I9_9AVES

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • BW47
    • BW54
    • BW59
    • BW63
    • BW64
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Aequornithes > Procellariiformes > Procellariidae > Puffinus

Accessions

  • Primary accession
    A0A3G1T2I9

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-42Helical
Transmembrane63-85Helical
Transmembrane105-130Helical
Transmembrane142-169Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-185Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    185
  • Mass (Da)
    19,536
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    39EB19F31DB081977339FEB2C39FFC3A
GQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPVMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSTVEAGAGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGVSSILGAINFITTAINMKPPALSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue185

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH383369
EMBL· GenBank· DDBJ
AXY96883.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383370
EMBL· GenBank· DDBJ
AXY96884.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383377
EMBL· GenBank· DDBJ
AXY96891.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383382
EMBL· GenBank· DDBJ
AXY96896.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383383
EMBL· GenBank· DDBJ
AXY96897.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383384
EMBL· GenBank· DDBJ
AXY96898.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383386
EMBL· GenBank· DDBJ
AXY96900.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383387
EMBL· GenBank· DDBJ
AXY96901.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383388
EMBL· GenBank· DDBJ
AXY96902.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383389
EMBL· GenBank· DDBJ
AXY96903.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383390
EMBL· GenBank· DDBJ
AXY96904.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383391
EMBL· GenBank· DDBJ
AXY96905.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383392
EMBL· GenBank· DDBJ
AXY96906.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383393
EMBL· GenBank· DDBJ
AXY96907.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383394
EMBL· GenBank· DDBJ
AXY96908.1
EMBL· GenBank· DDBJ
Genomic DNA
MH383395
EMBL· GenBank· DDBJ
AXY96909.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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