A0A3G1IZE6 · A0A3G1IZE6_9RHOD

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    cox1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MG_240A
    • MLG_227D
    • MLG_227F
    • MLG_228C
    • MLG_228E
  • Taxonomic lineage
    Eukaryota > Rhodophyta > Bangiophyceae > Bangiales > Bangiaceae > Pyropia

Accessions

  • Primary accession
    A0A3G1IZE6

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane34-55Helical
Transmembrane76-98Helical
Transmembrane118-143Helical
Transmembrane155-182Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-210Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    210
  • Mass (Da)
    22,920
  • Last updated
    2019-02-13 v1
  • Checksum
    68064930BD27C14A
ACASILIRMELAQPGNQLLLGNHQVYNVLVTEHAFLMIFFMVMPVLIGGFGNWFVPIMIGAPDMAFPRLNNISFWLLPPSLCLLLGSAMVEVGAGTGWTLYPPLSSIQSHSGGAVDLAIFSLHLSGASSILGAINFITTIFNMRNPGQSMYRIPLFVWSILITALLLLLAVPVLAGAITMLLTDRNFNTTFFDPSGGGDPVLYQHLFWFF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue210

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY560091
EMBL· GenBank· DDBJ
ASU64289.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560092
EMBL· GenBank· DDBJ
ASU64290.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560095
EMBL· GenBank· DDBJ
ASU64293.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560097
EMBL· GenBank· DDBJ
ASU64295.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560099
EMBL· GenBank· DDBJ
ASU64297.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560100
EMBL· GenBank· DDBJ
ASU64298.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560101
EMBL· GenBank· DDBJ
ASU64299.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560102
EMBL· GenBank· DDBJ
ASU64300.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560103
EMBL· GenBank· DDBJ
ASU64301.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560104
EMBL· GenBank· DDBJ
ASU64302.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560105
EMBL· GenBank· DDBJ
ASU64303.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560106
EMBL· GenBank· DDBJ
ASU64304.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560107
EMBL· GenBank· DDBJ
ASU64305.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560108
EMBL· GenBank· DDBJ
ASU64306.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560111
EMBL· GenBank· DDBJ
ASU64309.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560113
EMBL· GenBank· DDBJ
ASU64311.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560117
EMBL· GenBank· DDBJ
ASU64315.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560119
EMBL· GenBank· DDBJ
ASU64317.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560121
EMBL· GenBank· DDBJ
ASU64319.1
EMBL· GenBank· DDBJ
Genomic DNA
KY560124
EMBL· GenBank· DDBJ
ASU64322.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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