A0A3G1IZE6 · A0A3G1IZE6_9RHOD
- ProteinCytochrome c oxidase subunit 1
- Genecox1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids210 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Rhodophyta > Bangiophyceae > Bangiales > Bangiaceae > Pyropia
Accessions
- Primary accessionA0A3G1IZE6
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 34-55 | Helical | |||
Transmembrane | 76-98 | Helical | |||
Transmembrane | 118-143 | Helical | |||
Transmembrane | 155-182 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length210
- Mass (Da)22,920
- Last updated2019-02-13 v1
- Checksum68064930BD27C14A
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 210 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY560091 EMBL· GenBank· DDBJ | ASU64289.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560092 EMBL· GenBank· DDBJ | ASU64290.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560095 EMBL· GenBank· DDBJ | ASU64293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560097 EMBL· GenBank· DDBJ | ASU64295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560099 EMBL· GenBank· DDBJ | ASU64297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560100 EMBL· GenBank· DDBJ | ASU64298.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560101 EMBL· GenBank· DDBJ | ASU64299.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560102 EMBL· GenBank· DDBJ | ASU64300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560103 EMBL· GenBank· DDBJ | ASU64301.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560104 EMBL· GenBank· DDBJ | ASU64302.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560105 EMBL· GenBank· DDBJ | ASU64303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560106 EMBL· GenBank· DDBJ | ASU64304.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560107 EMBL· GenBank· DDBJ | ASU64305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560108 EMBL· GenBank· DDBJ | ASU64306.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560111 EMBL· GenBank· DDBJ | ASU64309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560113 EMBL· GenBank· DDBJ | ASU64311.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560117 EMBL· GenBank· DDBJ | ASU64315.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560119 EMBL· GenBank· DDBJ | ASU64317.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560121 EMBL· GenBank· DDBJ | ASU64319.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY560124 EMBL· GenBank· DDBJ | ASU64322.1 EMBL· GenBank· DDBJ | Genomic DNA |