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A0A3G1DJJ7 · MFL3_PHOSM

Function

function

Transcription factor that likely regulates the expression of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a lead compound for the treatment of hyper-cholesterolemia by targeting squalene synthase (SS).

Features

Showing features for dna binding.

112321002003004005006007008009001,0001,1001,200
TypeIDPosition(s)Description
DNA binding763-790Zn2-C6 fungal-type

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Squalestatin S1 biosynthesis transcriptional activator L3

Gene names

    • Name
      L3

Organism names

Accessions

  • Primary accession
    A0A3G1DJJ7

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004478291-1232Squalestatin S1 biosynthesis transcriptional activator L3

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region33-94Disordered
Region182-330Disordered
Compositional bias187-270Polar residues
Compositional bias284-314Polar residues
Region355-402Disordered
Compositional bias367-381Polar residues
Region438-484Disordered
Compositional bias459-484Basic and acidic residues
Region502-525Disordered
Region572-682Disordered
Compositional bias585-599Polar residues
Compositional bias607-631Polar residues
Compositional bias636-651Pro residues
Compositional bias657-682Basic and acidic residues

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,232
  • Mass (Da)
    136,132
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    7FC18C06977BD1EFE3C0F3F0D41F810B
MSLSIPGLEYCRFRQTSRALRRILSFSTTTSPCFADRSTEGMSKRREHPPLPGKQQDIWPPSLSGMEQPVPSFKSFIRKTPPPTGSPGEKPLPPLPTLHRESVDTTPSAAINTSPTRTPSVPFWKAPANWDDSSTPVQEHQAPPVFSPRNYALLLPEASPGGLDSNEPTQWPFDVAATHHPRLNSIDEQVDQVSLSSACHLSAASASRSSSPRPDDDPSTLSSNSNNDRLVINTTKLYSTSSESSASHNMSPVSPSEVMFSPSNVSTKQKVFGIELPGGPGTTIEDWSSRTPSNPRSETPKSGLSMQGKKLQRLNRPISTIDPHPSDPDISAKAQHLDASLDYHSVLAGVYHEEHAHDARPTAARQKNKVPPSTRINPGKQRSGNREMVPRPLSWRKDSNSSFPNSALVDIEEDPKRVPNSRKRYRKMTNWVPFHQPMHMHKGVSQRVEETGSNNGSRYPKRKGKDSPESGGVHGKEADGKSLMPHVRDFATHVKNGIVSTSHAANRSITSSPSQPSTASTPPRAEQHTRLIRLGGGFALVRQSPAVTPPSHSSSRLDISLPLQAPVSRSYGQIPDIEVEPVSRRPSSLYSQQSEAPVAPGISVNKRNLRISPSLSPQTRSNTSSPPTSPLAHEVSFPRTPPPPARSPNRPPYRPQKGAEVVEDERVDSANEDKSHKKSLHVGIMDMARDARHAWKKHHQDAKHEKLKQSIRVLGPTDPGVAAAGVLVHLTPKAFIHHSSLLNTRTMRTLTIPAAVVKRKQACNSCRHRKRKCDAERPVCGLCRRWGIACEYNVPAAERGNPATGTAQPLQAPTRVPVLPGINVDAREAFPDAQTIGLDLDFTSAESGFGYPALQSISQSRNAPNDQDPIASFQLPNHDLLVEMVTLFFDNLYHLFPCFHRKEFMKQLEEGTIQKESTLILFSMCCLAARVHPDAAVKKRQQEWYEQAKFSYQLTQRDPYPALRTIQAALLLIAHASTAGDFSSSWLFLGKVWRQAVALGINRMDTRNAASMGIKPQHWNSGHEQVYGLDKKEGRNAVEKEEYRRTLWLLLVMDRNHAWPTGWPNALPISHFKVDLPIADSLFQEMTPEVQDAPSSNVPFVRNFSCLLGSLSSVTNPAVNVFQYICVAYVLLGQVSEVVHTLQDEVDTLEYLQACEELDSQIVKLRLSLPRKATSILEASPEDRGHVVWLQVMLNSCAMLLYYRCVKDESPKDDATNTFLHAVTAAQNVAQV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias187-270Polar residues
Compositional bias284-314Polar residues
Compositional bias367-381Polar residues
Compositional bias459-484Basic and acidic residues
Compositional bias585-599Polar residues
Compositional bias607-631Polar residues
Compositional bias636-651Pro residues
Compositional bias657-682Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU946987
EMBL· GenBank· DDBJ
AMY15054.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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