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A0A3G1DJG1 · MFM2_PHOSM

Function

function

MFS-type transporter; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    MFS-type transporter M2
  • Alternative names
    • Squalestatin S1 biosynthesis cluster protein M2

Gene names

    • Name
      M2

Organism names

Accessions

  • Primary accession
    A0A3G1DJG1

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane22-42Helical
Transmembrane59-79Helical
Transmembrane89-109Helical
Transmembrane120-140Helical
Transmembrane150-170Helical
Transmembrane179-199Helical
Transmembrane217-237Helical
Transmembrane247-267Helical
Transmembrane269-289Helical
Transmembrane319-339Helical
Transmembrane346-366Helical
Transmembrane379-399Helical
Transmembrane419-441Helical
Transmembrane479-499Helical

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00004478301-563MFS-type transporter M2
Glycosylation5N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Induction

Expression is induced on squalestatin S1-producing YMG medium.

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias504-525Basic and acidic residues
Region504-563Disordered
Compositional bias547-563Basic and acidic residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    563
  • Mass (Da)
    60,408
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    02E37B4E8BD1AE1FB4EB5BFB4F6A30B7
MAHTNTSTALHEQENFLPKNRLLLVILTLGTVLFVINIDHNGLSTLLPTIAEDLGAQKSITWAGSSQLIATTVFSVLYGRLSDIFGRKALFVSALGVFSIAELGCGFANSPRMLYAMRALTGASGGGIGNLSIIIATDVVSLRHRGQYMAVVAPFMVLGNVCGPLVAAGVAKSSLTWRGLFWLISPLGGLSAILAGYILPSTAPTDTFKQNLAKVDWLGSLTSTVAIVGFMVAVSGTGTYHPGYSPLAISLLSVSGAAFLAFLFIEWKFATLPIIPLTIFAIPDVSALLMQTFTLGWVNQANVYFIPIYAQNLRQWSPVISGVLLFPIIAVQVIVSMIAGRWMSKSGQYGTTIRLGVAFLLIGSLLETQFGRSTHPAYVVIVLLVIGIGVGAANQPMVIAMQAHTKKSERAVVTSSRNFFRFLGSACGVAMSAAILQSTLRASLPVAYKHLAESPYALAGLSPQERDVIAPSYERAIRHVFIASAGASVLCSLGLFVWKDDGYESRPNEDNDNDQHASTRETDEEDEQSTLIDNREPSAVSYGTVEAGERDRYKAPDRLRRGL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias504-525Basic and acidic residues
Compositional bias547-563Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU946987
EMBL· GenBank· DDBJ
AMY15059.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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