A0A3G1DIJ8 · MFM6_PHOSM

Function

function

MFS-type transporter; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    MFS-type transporter M6
  • Alternative names
    • Squalestatin S1 biosynthesis cluster protein M6

Gene names

    • Name
      M6

Organism names

Accessions

  • Primary accession
    A0A3G1DIJ8

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane81-101Helical
Transmembrane146-166Helical
Transmembrane206-226Helical
Transmembrane236-256Helical
Transmembrane317-337Helical
Transmembrane347-367Helical
Transmembrane407-427Helical
Transmembrane432-452Helical
Transmembrane469-489Helical
Transmembrane496-516Helical

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00004478311-547MFS-type transporter M6
Glycosylation118N-linked (GlcNAc...) asparagine
Glycosylation167N-linked (GlcNAc...) asparagine
Glycosylation274N-linked (GlcNAc...) asparagine
Glycosylation493N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-45Disordered
Compositional bias27-43Basic and acidic residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    547
  • Mass (Da)
    59,863
  • Last updated
    2019-02-13 v1
  • Checksum
    F344C16A8AEA6B6D
MHRRRRDNLMTPAEMVASMKPPQSLSTEDDDGSRRDSESSADVLKSNEEFQARMIPEDDDANSVTAQPTWTVLSDTEIKSVLVVASFAAAISPFSTSTYYPAVFAISQDLGVSVSKINLTMSSYQIFQGVAPTITAAFADTYGRRPMFLVCFAIYFVANVGLALQNNFTTLLVLRCLQSTGSSGTFALAQAVTADITTRAERGRYLIYATLGSTLGPFLGPVIGGLLVKFLGWRSVFWFLLCMGTVFALLIFIFFGETARPIVGDGSVPPQSWNRSFLQIRSKGITSLKPNLASLERRKSRPNPLTSLALLWDRENFILSVSGGLLYAGYSSVTSVLASQLQQRYKYDAVQVGLCYLPVGFGSLLAYRTTVRLMDWNFEREAKKQGLVIVKNQQTDITRFDLEKARLGFVFPMILVCSVLLVAYGWQMHYHAPLAPILVTMFLIAIILTGVMNAIAALLTDVNRENAAAVGAAMNLTRLLLGAGAVAVVGPLNKSAGIGWTATVTAGLWVLMMPTLRMVYRDGFVWRAGENERVHASNVELAALVRS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias27-43Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU946987
EMBL· GenBank· DDBJ
AMY15063.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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