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A0A3F3JMH9 · A0A3F3JMH9_ENTFC

Function

function

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Miscellaneous

This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site118Nucleophile; methyl group acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmethylated-DNA-[protein]-cysteine S-methyltransferase activity
Biological ProcessDNA alkylation repair
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylated-DNA--protein-cysteine methyltransferase
  • EC number
  • Alternative names
    • 6-O-methylguanine-DNA methyltransferase
      (MGMT
      )
    • O-6-methylguanine-DNA-alkyltransferase

Gene names

    • ORF names
      HV425_09400

Organism names

Accessions

  • Primary accession
    A0A3F3JMH9

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the MGMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    154
  • Mass (Da)
    17,219
  • Last updated
    2019-01-16 v1
  • MD5 Checksum
    F38D759B7D27490CBAF5A4B2FBAEF1B2
MKIHTPIGFLWLDADESGLTAVSFQPISESESANQQILTRTQEQFEEYFAGKRKEFEVPLSIKRGTPFQQNVWKALSTIPYGEIRTYKEVAVAVDSPKAVRAIGQANRTNPLPIVIPCHRVIGQNGKLTGYMGNATDGVEIKRQLLLLEGYLQN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABWVJ010000004
EMBL· GenBank· DDBJ
NVD82984.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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