A0A3D9DE00 · A0A3D9DE00_9FLAO
- ProteintRNA-dihydrouridine synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids331 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
Catalytic activity
- a 5,6-dihydrouridine in tRNA + NAD+ = a uridine in tRNA + H+ + NADH
- a 5,6-dihydrouridine in tRNA + NADP+ = a uridine in tRNA + H+ + NADPH
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | RNA binding | |
Molecular Function | tRNA dihydrouridine synthase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA-dihydrouridine synthase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Weeksellaceae > Chryseobacterium group > Chryseobacterium
Accessions
- Primary accessionA0A3D9DE00
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-318 | DUS-like FMN-binding | ||||
Sequence: LLAPMEDVSDPPFRRLCKMHGADLMYSEFISSEGLIRDAMKSRKKLDIFDYERPVGIQIFGGDEEAMAMSARIVETVNPDLVDINFGCPVKKVVCKGAGAGVLKDIDLMVRLTKAVVNSTHLPVTVKTRLGWDSTSINIDEVAERLQETGIKALTIHARTRAQMYKGEADWEHISRIKQNPNIEIPIFGNGDIDSPEKALEYKQKYACDGIMIGRAAIGYPWIFNEIKHFFKTGEHLPEPVIADRLLAVRQHAEWSAEWKGEKLGLIEMRQHYSNYFRGVPHFKEFRKKFLEVFTLEEMNALIK |
Sequence similarities
Belongs to the dus family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length331
- Mass (Da)37,851
- Last updated2019-01-16 v1
- ChecksumA72EAA2191FE6977