A0A3D8ZEE9 · A0A3D8ZEE9_STAPS

Function

function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site.

166050100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site40-47ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentexcinuclease repair complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular Functionexcinuclease ABC activity
Biological Processnucleotide-excision repair
Biological ProcessSOS response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    UvrABC system protein B
  • Short names
    Protein UvrB
  • Alternative names
    • Excinuclease ABC subunit B

Gene names

    • Name
      uvrB
    • ORF names
      DV961_09050

Organism names

  • Taxonomic identifier
  • Strain
    • ST496-2
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus > Staphylococcus intermedius group

Accessions

  • Primary accession
    A0A3D8ZEE9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.

Family & Domains

Features

Showing features for domain, motif, region.

Type
IDPosition(s)Description
Domain27-161Helicase ATP-binding
Motif93-116Beta-hairpin
Domain431-597Helicase C-terminal
Region603-623Disordered
Domain624-659UVR

Domain

The beta-hairpin motif is involved in DNA binding.

Sequence similarities

Belongs to the UvrB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    660
  • Mass (Da)
    76,358
  • Last updated
    2019-01-16 v1
  • Checksum
    C99DBDDE8E676DAA
MEHHDFKIASNFEPQGDQPQAIKALVKGIEEGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKTFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPDEYRDLVVSIRLGMEMDRSELLRKLVDVQYTRNDIDFRRGTFRVRGDVVEIFPASREELCIRVEFFGDEVDRISEINYLTGEVLKEREHFALFPASHFVTREEKMKIAIERIEKELEEQLAYLRSENKLLEAQRLEQRTNYDLEMMREMGFTSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLIMIDESHVTLPQIRGMYNGDQARKQVLVEHGFRLPSALDNRPLKFEEFEQKAKQLVYVSATPGPYEIEHTDEMIEQIIRPTGLLDPKIEVRPTKNQIDDLLSEIQERTEQGERVLITTLTKKMSEDLTTYLKEAGVKVNYLHSEIKTLERIEIIRDLRMGTFDVLIGINLLREGLDIPEVSLVVILDADKEGFLRSERSLIQTMGRAARNDKGHVIMYADRITDSMKVAIDETERRREIQIAYNEKHGIVPKTINKEIHDVISATVETDETNEDQRKEVPKKMTKKEREKTIENVEKEMKEAAKALDFERATELRDLLFELKSKG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QQPC01000062
EMBL· GenBank· DDBJ
REA80895.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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